НЕЙРОБИОН / NEUROBION N20 tablets (vit b1, vit b6 and vit b12 deficiency)

Merck KGaA (Austria)

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Description / Instructions
Pharmacological properties
Pharmacodynamics. The product contains a combination of active substances of neurotropic vitamins of the complex B. Included in the vitamins: thiamine (B1), pyridoxine (B6) and cyanocobalamin (B12) play a special role as a coenzyme in intermediary metabolism in the CNS and peripheral nervous sisteme.Kak and all other vitamins they are essential nutrients which can not be synthesized directly administering a organizme.Terapevticheskoe vitamins B1, B6 and B12 compensates for insufficient dietary intake of vitamins, which ensures the presence in the body coenzymes required amount. The combined use of B vitamins increases their therapeutic efficacy because it is believed that the effectiveness of the combination is greater than the efficiency of its individual komponentov.Terapevticheskoe use of these vitamins in different diseases of the nervous system is aimed at, on the one hand, to compensate for both the existing failure (possibly due to increasing needs of the body, caused by the disease itself), and the other - to stimulate the natural mechanisms of the rebels occurrence. At the same time, the analgesic action of vitamin B complex has a positive effect on the therapeutic rezultat.Farmakokinetika. Thiamine. After oral administration, carried out by its metered transport mechanism which has a dual nature: an active suction to a concentration of 2 mol and passive diffusion at concentrations> 2 mol. TЅ is about 4 hours. In the human body can be up to 30 mg of thiamine. Given the rapid metabolism of buffer stocks are very limited, they are consumed by 4-10 dney.Piridoksin. Pyridoxine is absorbed very quickly, mainly in the upper gastrointestinal tract, maximum output 2-5 Cv humans may be about 40-150 mg; 1,7-3,6 mg excreted in the urine for sutki.Tsianokobalamin. Vitamin B12 is absorbed in the intestine by two mechanisms: release under the action of gastric juice and quick connection with intrinsic factor;regardless of the intrinsic factor, due to the passive contact with krov.Pri doses> 1.5 mg latter mechanism plays a significant rol.U patients with pernicious anemia absorbed about 1% after administration of doses
as maintenance therapy of neuritis and neuralgia, such as trigeminal neuralgia, intercostal neuralgia, sciatica, lumbar syndrome (lumbago) ; plexitis (cervical and brachial plexus), radicular neuritis due to degenerative diseases of the spine; prozoplegiya (facial nerve damage).
vnutr.Vzroslye and adolescents aged over 15 years: 1 tablet 3 times a day. Tablets should be taken tse lymi with some liquid after meals. Duration of the course determined by the physician individually in each case.
hypersensitivity to the drug.
Side Effects
hypersensitivity reactions occurring mainly in the form of cutaneous phenomena rarely occur after administration of vitamin B1 and vitamin B12.
when administered vitamin B12 clinical picture and laboratory parameters at the funicular myelosis or pernicious anemia may lose their spetsifichnost.Period pregnancy and lactation.Today there is no d op ponents of adverse effects during pregnancy after the introduction of vitamins B1, B6 and B12 in the recommended dozah.Issledovany of a possible accumulation of these vitamins in breast milk higher than physiological norms are not carried out.
with the concomitant use of vitamin B6 with levodopa may reduce the anti-Parkinsonian effect of levodopa.
An overdose of
vitamins B1, B6 and B12 have a broad therapeutic diapazonom.Vitamin B1. There are such symptoms after dosing, exceeding more than 100 times the recommended: headache, cramps, weakness, paralysis, cardiac arrhythmia and allergic reaktsii.Vitamin B6. Neuropathy ataxia and sensory disturbances, cerebrovascular cial seizures with ECG changes, and in some cases, hypochromic anemia and seborrheic dermatitis have been described after the administration of doses in excess of 2 g / sut.Vitamin B12. After parenteral administration of the drug at the high dose were observed allergic reactions, eczema, and skin disorders benign form of acne.
at temperatures above 25 ° C.