active methionine, ACIMETHIN, urinary tract infections, urinary acidifiers ingredients

• 500 mg methionine

ACIMETHIN, urinary tract infections, methionine, urinary acidifiers excipients

• Povidone K30
• Magnesium stearate (vegetable)
• crospovidone
• silica
• Silica, colloidal
• Carboxymethyl Starch, Sodium Type A
• cellulose, microcrystalline
• Macrogol 6000
• talc
• Butyl methacrylate copolymer, basic
• titanium dioxide
• hypromellose
• ferric oxide

Indication/ ACIMETHIN, methionine, urinary tract infections, urinary acidifiers Application

• The drug is a physiological urological drug.
• It is applied
  • as a urinary acidifier
    • with bacteriostatic effect in urinary tract infections, also for prevention in patients with neurogenic bladder dysfunction
    • to optimize the effect of antibiotics with optimum effect in acidic urine (pH 4-6):
      • e.g. B. ampicillin, carbenicillin, sulfonamides, nalidixic acid, nitrofurantoin
    • to avoid the formation of new stones in phosphate stones (struvite, carbonate apatite, brushite).

ACIMETHIN, methionine, urinary tract infections, urinary acidifiers dosage

• Always take this medicine exactly as described here or as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
• Unless otherwise prescribed by the doctor, the recommended dose is
  • In general, 1-2 film-coated tablets 3 times a day are sufficient. In order to achieve rapid urinary acidification, it makes sense to start the therapy with 2 film-coated tablets 3 times a day.
  • In special cases and on doctor's orders, higher doses can be taken by patients who are not at risk of acidosis.
• A pH value of the urine of less than pH 6 is therapeutically aimed at. It must be taken into account that the effect can only occur after 5 - 6 days.
• children
  • There are no adequate studies on use in children.
  • The drug should therefore not be used in children under 12 years of age.

• duration of use
  • The duration of use is determined by the doctor and depends solely on the therapeutic need.

• If you take more than you should
  • Methionine, the drug's active ingredient, is one of the amino acids that the human body cannot produce itself, but which it needs to build protein. Many foods contain methionine naturally.
  • Intoxications (overdose symptoms) have not occurred so far.

• If you forget to take a dose
  • Do not take a double dose to make up for a forgotten dose.

• If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

ACIMETHIN, urinary tract infections, urinary acidifiers way, methionine

• The film-coated tablets are swallowed whole with some liquid before meals.

side effects

• Like all medicines, this medicine can cause side effects, although not everybody gets them.
• In patients at risk of acidosis, shifts in the blood pH value into the acidic range are possible.
• Taking the drug can cause vomiting, nausea, diarrhea, drowsiness, and irritability.
• If you get any side effects, talk to your doctor or pharmacist. This also applies to side effects that are not specified.

methionine interactions

• Taking with other medicines
  • Tell your doctor or pharmacist if you are taking/using, have recently taken/used or might take/use any other medicines.
  • With the simultaneous administration of active substances (e.g. ampicillin, carbenicillin, sulfonamides, nitrofurantoin and nalidixic acid), which are reabsorbed to a greater extent due to the acidification of the urine in the kidneys, the effect can be increased by prolonging the plasma half-life.
  • Concomitant administration of levodopa and methionine can lead to a worsening of the effectiveness of levodopa in patients with Parkinson's disease. Increased dosage of methionine should be avoided in these patients.

Contraindications

• The drug must not be taken
  • if you are allergic to methionine or any of the other ingredients of this medicine
  • in homocysteinuria (congenital metabolic disease)
  • for uric acid and cystine stones (metabolic products)
  • in case of renal insufficiency (limited renal function)
  • in oxalosis (increased deposition of calcium oxalate crystals in kidney tissues and/or other organs)
  • with methionine adenosyltransferase deficiency (metabolic disease)
  • in metabolic (e.g. renal tubular) acidosis (blood acidification)
  • in infants.

pregnancy and breast feeding period

• If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
• There are insufficient data on the use of methionine during pregnancy and lactation. Pregnant and breastfeeding women should only take the medicine after a careful benefit-risk assessment by their doctor.

patient methionine, ACIMETHIN, urinary tract infections, urinary acidifiers notes

• Warnings and Precautions
  • Please talk to your doctor or pharmacist before taking this medicine.
  • Because of the risk of synthesis of neurotoxic mercaptans in bacterial metabolism, patients with liver dysfunction or hepatogenic encephalopathy (brain changes caused by liver disease) should not take methionine.
  • What precautions should be taken?
    • If there is a deficiency in folic acid, vitamin B2, B6 and/or B12, treatment with methionine can lead to an increase in the homocysteine ​​level. An increased occurrence of homocysteine ​​in the blood can be regarded as an independent risk factor for the changes in the wall of the blood vessels that lead to "calcification". With long-term use of the drug, it is therefore important to ensure an adequate supply of folic acid and B vitamins through the diet supplementary income.
    • The homocysteine ​​plasma level can be increased under a hypothyroid metabolic situation (underactive thyroid gland). Thyroid function should therefore be checked prior to treatment with methionine.
    • Exposure to methionine can lead to increased excretion of calcium in the urine (hypercalcuria). In the case of long-term treatment, regular monitoring of the mineral balance is therefore important.
    • In patients at risk of acidosis, long-term treatment with the drug should be carried out with regular monitoring of the acid-base balance in the blood.