• 500 mg methionine

• Cellulose, microcrystalline
• Croscarmellose sodium
• Hypromellose
• Macrogol 6000
• Magnesium stearate (vegetable)
• Poly (ethyl acrylate-co-methyl methacrylate) (2: 1)
• Silicon dioxide, finely divided
• Corn starch, pre-gelatinized
• talc
• Titanium dioxide

Indication / application

• The medicine is a urological agent.
• It is applied
  • For urinary acidification with the therapeutic goal:
    • Optimization of the effect of antibiotics with optimum effect in acidic urine (pH 4 - 6): z. B. ampicillin, carbenicillin, nalidixic acid, nitrofurans.
    • Avoiding the formation of new stones with phosphate stones (struvite, carbonate apatite, brushite).
    • Inhibition of bacterial growth.

dosage

• Always take the medicine exactly as directed. Please ask your doctor or pharmacist if you are not sure.
  • Unless otherwise prescribed by your doctor, the usual dose is:
    • 1 - 2 tablets 3 times a day (equivalent to 0.5 - 1 g methionine 3 times a day).
    • In patients who are not at risk of acidosis, the dosage can be increased to 10 g / day in special cases.
    • The therapeutic aim is to have a urine pH of less than 6. It must be taken into account that the drug can only take effect after 5 - 6 days.

• Duration of application
  • The duration of use depends solely on the therapeutic necessity.
  • Please talk to your doctor if you have the impression that the effect of the drug is too strong or too weak.

• If you take more than you should
  • Cases of overdose are not yet known.

• If you forget to take a dose
  • If you have forgotten to take a dose, do not take it up, but continue with the next dose as described in the dosage instructions.

• If you have any further questions on the use of the medicinal product, ask your doctor or pharmacist.

way

• To take.
• Please take the film-coated tablets with sufficient liquid (e.g. a glass of water).

Side effects

• Like all medicines, the preparation can cause side effects, although not everybody gets them. When evaluating side effects, the following frequencies are usually used as a basis:
  • Very often:
    • More than 1 in 10 people treated
  • Often:
    • Less than 1 in 10 but more than 1 in 100 patients
  • Occasionally:
    • Less than 1 in 100 but more than 1 in 1000 people treated
  • Rarely:
    • Less than 1 in 1000 but more than 1 in 10,000 people treated
  • Very rare:
    • Less than 1 in 10,000 people, including isolated cases
• Psychiatric illness
  • Irritability.
• Nervous system disorders
  • Sleepiness.
• Gastrointestinal disorders
  • Vomiting, nausea.
• Investigations
  • In patients at risk of acidosis, the blood pH value may shift to the acidic range.
• If you get any side effects, talk to your doctor or pharmacist. This also applies to side effects that are not specified.

Interactions

• When taking with other medicines
  • Please tell your doctor or pharmacist if you are taking / using or have recently taken / used any other medicines, including medicines obtained without a prescription.
  • The medicine can make L-dopa less effective in patients with Parkinson's disease. Increased methionine doses should be avoided in these patients.
  • The film-coated tablets can reduce the effects of active ingredients such as B. Increase penicillins, sulfonamides and nalidixic acid.
  • Please note that this information can also apply to recently used drugs.

Contraindications

• The medicine must not be taken
  • if you are hypersensitive to the active ingredient or any of the other ingredients.
  • with congenital metabolic disease (homocysteinuria)
  • for uric acid and cystine stones
  • with renal insufficiency
  • with oxalosis (increased deposition of calcium oxalate crystals in kidney tissue and / or other organs)
  • in the case of methionine adenosyl transferase deficiency
  • in metabolic and renal tubular acidosis
  • in infants.

pregnancy and breast feeding period

• There are insufficient data on the use of methionine during pregnancy and lactation. Pregnant and breastfeeding women should only take the drug after a careful risk-benefit assessment by the doctor.

Patient information

• Take special care when taking it
  • Because of the risk of the synthesis of neurotoxic mercaptans in the bacterial metabolism, methionine should not be administered to patients with hepatic insufficiency or hepatogenic encephalopathy.
  • If there is a deficiency in folic acid, vitamins B ₂ , B ₆ and / or B ₁₂ , methionine treatment can lead to an increase in the homocysteine ​​blood level. With long-term use of the film-coated tablets, it is therefore important to ensure a diet rich in folic acid and vitamin B.
  • In the context of an underactive thyroid, the homocysteine ​​blood level can be increased. Thyroid function should therefore be checked before treatment with methionine.
  • Treatment with methionine may increase the excretion of calcium in the urine. In the case of long-term use of the film-coated tablets, regular control of the mineral balance should therefore be ensured.
  • In patients at risk of acidosis, long-term treatment with methionine should be carried out with regular monitoring of the acid-base balance in the blood.
  • children
    • There is insufficient research into the use of this medicine in children. The film-coated tablets should therefore not be used in children under 12 years of age.

• Driving and using machines
  • No known effects.