Apap Migraine x 20 tablets

• The Apap Migrena medicinal product contains three active substances – paracetamol, acetylsalicylic acid and caffeine. The indication for the use of the drug is the treatment of headache or migraine in adults. The preparation is for short-term use.

Apap Migraine Composition:

Active substances: acetylsalicylic acid (Acidum acetylsalicylicum), paracetamol (Paracetamolum) and caffeine (Coffeinum). Each coated tablet contains 250mg of acetylsalicylic acid, 250mg of paracetamol and 65mg of caffeine and excipients: microcrystalline cellulose, low-substituted hydroxypropylcellulose, stearic acid 50. Coating: Forcoat White W010 (hypromellose, titanium dioxide (E 171), propylene glycol, benzoic acid), carnauba wax.

Apap Migraine action:

The drug is produced by three active substances. Apap Migrena contains acetylsalicylic acid, paracetamol and caffeine. Paracetamol and acetylsalicylic acid reduce fever and pain. Caffeine is a mild stimulant, and it also increases the effect of acetylsalicylic acid and paracetamol. The drug is indicated for occasional use in the treatment of headache and migraine attacks with symptoms such as headache, nausea, sensitivity to light and sound, and disturbances in daily functioning – with or without aura. The drug can be used by people over 18 years of age.

Application:
Apap Migrena is a medicinal product indicated for the short-term treatment of headache and migraine attacks (its symptoms include: headache, nausea, sensitivity to light and sound, and disturbances in daily functioning) with or without aura. The medicine is for adults - over 18 years of age.

Additional information:
Store the product out of reach of children, at room temperature. It is recommended to protect from moisture and light. The medicine contains paracetamol. Do not take more than the recommended dose, as it may cause serious liver damage. Acetylsalicylic acid may cause bleeding - if unusual bleeding occurs, inform your doctor. You should consult your doctor before using the medicine if: you have not previously been diagnosed with migraine, because in such a case other potentially serious conditions related to the brain or nervous system should be ruled out before using the medicine; the migraine is so severe that you need to lie down in bed, or because of pain that is different from the migraines you usually have, the migraine headaches are accompanied by vomiting; you have headaches after a head injury or caused by a head injury, fatigue, coughing or a bent over position; the headaches are chronic (15 or more days a month for more than 3 months) or the headaches occurred for the first time after the age of 50; you have liver or kidney problems, are underweight, malnourished or regularly drink alcohol – it may be necessary to stop taking the medicine completely or reduce the amount of paracetamol you take; you have a severe infection, are seriously malnourished, are very underweight or chronically abuse alcohol, this may increase the risk of metabolic acidosis, which is manifested by, among others: deep, rapid, difficult breathing, feeling unwell (nausea, vomiting), loss of appetite. If these symptoms occur at the same time, contact your doctor immediately; you have a hereditary deficiency of glucose-6-phosphate dehydrogenase, which affects red blood cells – as a result, after eating certain types of food and taking other anti-inflammatory drugs (including acetylsalicylic acid), you may develop anemia, jaundice, an enlarged spleen or other diseases; you have ever had digestive system diseases such as stomach ulcers, bleeding from the digestive tract or black stools. If you have previously experienced stomach discomfort or heartburn after taking painkillers or anti-inflammatory drugs; have bleeding disorders or abnormal vaginal bleeding other than menstrual bleeding (e.g. abnormally heavy and prolonged menstrual bleeding); have recently undergone surgery (even minor ones such as dental surgery) or will undergo surgery within the next 7 days; have bronchial asthma, hay fever, nasal polyps, chronic obstructive pulmonary disease or have symptoms suggesting an allergy (skin reactions, itching, hives); have gout, diabetes, hyperthyroidism, heart rhythm disorders, uncontrolled hypertension,kidney or liver problems; have problems with alcohol abuse; are currently taking other medicines containing acetylsalicylic acid or paracetamol, or are taking other medicines, as some medicines may interact with the ingredients of this medicine and cause side effects; are at risk of dehydration (e.g. due to vomiting, diarrhoea, before or after major surgery); are under 18 years of age (there is a possible link between acetylsalicylic acid given to children and adolescents and the development of Reye's syndrome, therefore it should not be given to children and adolescents under 18 years of age without a doctor's recommendation). As with other medicines used to treat headaches, using this medicine too often (for 10 days or more per month) to treat chronic headache (for 15 days or more per month) lasting longer than 3 months may make your headache or migraine worse. If you feel that this has happened to you, talk to your doctor. You should feel better after stopping the medicine. The medicine may reduce the severity of the symptoms of infection (e.g. headaches, fever), which may make it more difficult to diagnose - therefore, if you feel unwell, tell your doctor that you are taking this medicine. The medicine may affect the results of some laboratory tests, so if you are going to have a blood, urine or other laboratory test, remember to tell your doctor that you are taking this medicine. The medicine contains 0.24 mg of propylene glycol and 0.05 mg of benzoic acid in one tablet. Benzoic acid may increase the risk of jaundice (yellowing of the skin and eyes) in newborns (up to 4 weeks of age). Use with other medicines: this should be discussed with your doctor, this is especially important when using medicines such as: other medicines containing paracetamol, acetylsalicylic acid or any other painkillers and antipyretics; Anticoagulants, e.g. oral anticoagulants (e.g. warfarin), heparin, thrombolytics (e.g. streptokinase), other antiplatelet agents (e.g. ticlopidine, cloprodogrel, cilostazol); corticosteroids (used to treat inflammation); barbiturates and benzodiazepines (used to treat anxiety and insomnia); lithium, selective serotonin reuptake inhibitors or fluvoxamine (used to treat depression); sulfonylurea or insulin (used to treat diabetes); methotrexate (used to treat certain types of cancer and arthritis); certain medicines to treat infections (e.g. rifampicin, isoniazid, chloramphenicol, ciprofloxacin,pipemidic acid); levothyroxine (treatment of hypothyroidism); metoclopramide (treatment of nausea and vomiting); medicines to treat epilepsy; medicines for high blood pressure and heart failure; diuretics (used to increase urine production and relieve water retention); medicines to treat gout; oral contraceptives; zidovudine (treatment of HIV infection); medicines that delay stomach emptying e.g. propantheline; clozapine (treatment of schizophrenia); sympathomimetic medicines (increasing low blood pressure and treating nasal congestion); antiallergic medicines (prevention or treatment of allergies); theophylline (treatment of asthma); terbinafine (treatment of fungal infections); cimetidine (treatment of heartburn and peptic ulcers); disulfiram (treatment of alcohol addiction); nicotine (used to help stop smoking). cholestyramine (treatment of high blood cholesterol levels); flucloxacillin (antibiotic), due to the serious risk of a disorder affecting the blood and body fluids (high anion gap metabolic acidosis), which must be treated urgently and which may occur mainly in people with severe renal impairment, sepsis, malnutrition, chronic alcoholism, as well as in patients taking the maximum daily doses of paracetamol. Use with food and drink: ask your doctor whether you can take this medicine or other painkillers and antipyretics when consuming 3 or more alcoholic beverages a day. Paracetamol and acetylsalicylic acid can cause liver damage and stomach bleeding. Due to the caffeine content (in the recommended dose of the drug, the caffeine content is equivalent to about one cup of coffee), while using the drug, you should limit the consumption of medicines, food or drinks containing caffeine, too much of it can cause nervousness, irritability, insomnia and in some cases also an increased heart rate. Use during pregnancy and breastfeeding: consult your doctor, but the use of this medicine is not recommended during pregnancy and is contraindicated in the third trimester. Do not use the medicine during breastfeeding, as it may be dangerous for the infant. The medicine may impair fertility, this effect disappears after discontinuation of the preparation. Driving and operating machinery: the medicine has no effect, however, if side effects such as dizziness or drowsiness occur, avoid driving and operating machinery.propantheline; clozapine (treatment of schizophrenia); sympathomimetic drugs (increasing low blood pressure and treating nasal congestion); antiallergic drugs (prevention or treatment of allergies); theophylline (treatment of asthma); terbinafine (treatment of fungal infections); cimetidine (treatment of heartburn and peptic ulcers); disulfiram (treatment of alcohol addiction); nicotine (used to stop smoking); cholestyramine (treatment of high blood cholesterol); flucloxacillin (antibiotic), due to the serious risk of a disorder affecting the blood and body fluids (high anion gap metabolic acidosis), which must be treated urgently and which may occur mainly in people with severe renal impairment, sepsis, malnutrition, chronic alcoholism, as well as in patients taking the maximum daily doses of paracetamol. Use with food and drink: ask your doctor if you can take this medicine or other painkillers and antipyretics when consuming 3 or more alcoholic beverages a day. Paracetamol and acetylsalicylic acid can cause liver damage and stomach bleeding. Due to the caffeine content (in the recommended dose of the drug, the caffeine content is equivalent to the content of about one cup of coffee) while using the drug, limit the consumption of medicines, food or drinks containing caffeine, too much of it can cause nervousness, irritability, insomnia and in some cases also an increased heart rate. Use during pregnancy and breastfeeding: consult your doctor, but the use of this medicine is not recommended during pregnancy and is contraindicated in the third trimester. Do not use the medicine during breastfeeding, as it may be dangerous for the infant. The medicine may impair fertility, this effect disappears after discontinuation of the preparation. Driving and operating machinery: the medicine has no effect, however, if side effects such as dizziness or drowsiness occur, avoid driving and operating machinery.propantheline; clozapine (treatment of schizophrenia); sympathomimetic drugs (increasing low blood pressure and treating nasal congestion); antiallergic drugs (prevention or treatment of allergies); theophylline (treatment of asthma); terbinafine (treatment of fungal infections); cimetidine (treatment of heartburn and peptic ulcers); disulfiram (treatment of alcohol addiction); nicotine (used to stop smoking); cholestyramine (treatment of high blood cholesterol); flucloxacillin (antibiotic), due to the serious risk of a disorder affecting the blood and body fluids (high anion gap metabolic acidosis), which must be treated urgently and which may occur mainly in people with severe renal impairment, sepsis, malnutrition, chronic alcoholism, as well as in patients taking the maximum daily doses of paracetamol. Use with food and drink: ask your doctor if you can take this medicine or other painkillers and antipyretics when consuming 3 or more alcoholic beverages a day. Paracetamol and acetylsalicylic acid can cause liver damage and stomach bleeding. Due to the caffeine content (in the recommended dose of the drug, the caffeine content is equivalent to the content of about one cup of coffee) while using the drug, limit the consumption of medicines, food or drinks containing caffeine, too much of it can cause nervousness, irritability, insomnia and in some cases also an increased heart rate. Use during pregnancy and breastfeeding: consult your doctor, but the use of this medicine is not recommended during pregnancy and is contraindicated in the third trimester. Do not use the medicine during breastfeeding, as it may be dangerous for the infant. The medicine may impair fertility, this effect disappears after discontinuation of the preparation. Driving and operating machinery: the medicine has no effect, however, if side effects such as dizziness or drowsiness occur, avoid driving and operating machinery.Due to the caffeine content (the recommended dose of the drug contains caffeine equivalent to about one cup of coffee), when using the drug, you should limit your intake of drugs, foods or drinks containing caffeine, too much of it may cause nervousness, irritability, insomnia and in some cases also an increased heart rate. Use during pregnancy and breastfeeding: consult your doctor, but the use of this drug is not recommended during pregnancy and is contraindicated in the third trimester. Do not use the drug during breastfeeding, as it may be dangerous for the infant. The drug may impair fertility, this effect disappears after discontinuing use of the preparation. Driving and operating machinery: the drug has no effect, however, if side effects such as dizziness or drowsiness occur, avoid driving and operating machinery.Due to the caffeine content (the recommended dose of the drug contains caffeine equivalent to about one cup of coffee), when using the drug, you should limit your intake of drugs, foods or drinks containing caffeine, too much of it may cause nervousness, irritability, insomnia and in some cases also an increased heart rate. Use during pregnancy and breastfeeding: consult your doctor, but the use of this drug during pregnancy is not recommended and is contraindicated in the third trimester. Do not use the drug during breastfeeding, as it may be dangerous for the infant. The drug may impair fertility, this effect disappears after discontinuing use of the preparation. Driving and operating machinery: the drug has no effect, however, if side effects such as dizziness or drowsiness occur, avoid driving and operating machinery.

Contraindications:
Do not use in case of hypersensitivity to any of the ingredients of the drug. Do not use if you have ever had allergic reactions to other painkillers, anti-inflammatories or antipyretics, e.g. acetylsalicylic acid and salicylates or other anti-inflammatory drugs, e.g. diclofenac or ibuprofen (symptoms of an allergic reaction may be: asthma, wheezing or shortness of breath, rash or hives, swelling of the face or tongue; runny nose; if in doubt, consult your doctor or pharmacist). Do not use in people with stomach or intestinal ulcers, or if you have had gastrointestinal ulcers in the past. Do not use in case of blood in the stool or black stools (signs of gastrointestinal bleeding or perforation). Do not use in case of haemophilia or other blood diseases. Do not use in case of severe heart, liver or kidney diseases. Do not use if methotrexate is used in doses greater than 15 mg per week. Do not use in the third trimester of pregnancy.

Side effects:
Some people may experience side effects while taking this medicine. Stop taking the medicine and see a doctor immediately if you experience the following side effects: allergic reactions - swelling of the face, lips, mouth, tongue or throat (these symptoms may make swallowing difficult, cause wheezing, difficulty breathing, a feeling of tightness in the chest (asthma symptoms), rash, itching and fainting may also occur; redness of the skin, blisters on the lips, conjunctiva or mouth, peeling of the skin or mouth ulcers; bleeding from the stomach or intestines, ulceration of the stomach or intestines, these symptoms may be accompanied by severe abdominal pain, bloody or black stools or vomiting blood, these symptoms may not be preceded by warning symptoms and may occur with all non-steroidal anti-inflammatory drugs, at any stage of treatment and may lead to death. This risk is particularly high in the elderly; yellowing of the skin or eyes (signs of liver failure); dizziness or a feeling of "light-headedness" (sign of low blood pressure); irregular heartbeat - if you have had breathing problems after taking acetylsalicylic acid or non-steroidal anti-inflammatory drugs and have had a similar reaction after taking this product; unexplained bruising or bleeding; an increase in the number of nosebleeds or bruises; swelling or water retention; ringing in the ears or temporary loss of hearing; changes in behaviour, nausea and vomiting (these may be signs of Reye's syndrome). Side effects reported in clinical trials - common: nervousness, dizziness; nausea, abdominal discomfort; uncommon: insomnia, tremor, numbness, headache; tinnitus; dry mouth, diarrhoea, vomiting; tiredness, feeling anxious; rapid heartbeat; rare: sore throat, difficulty swallowing, numbness and tingling around the mouth, increased salivation; decreased appetite, taste disturbances; anxiety, euphoric mood, feeling tense; disturbance in attention, memory loss, impaired coordination; feeling of pain in the forehead and cheeks; eye pain, visual disturbances; hot flushes, problems with peripheral blood vessels (e.g. in the arms or legs); nose bleeds, shallow and slow breathing, runny nose; bloating, belching; excessive sweating, itching, itchy rash, increased skin sensitivity; stiffness in muscles, bones or joints, neck pain, back pain, muscle spasms; weakness, chest discomfort. Side effects reported from post-marketing experience: anxiety, feeling unwell or unusually unusual; drowsiness, migraine; skin redness, rash, very rare cases of serious skin reactions have been reported; palpitations, shortness of breath, sudden difficulty breathing, feeling of tightness in the chest,wheezing or coughing (symptoms of asthma); stomach pain, digestive discomfort after meals; increased levels of liver enzymes; swelling and irritation inside the nose; kidney problems.

Apap Migraine tablets dosage:

Use the medicine as directed by your doctor or as recommended on the leaflet. Adults (over 18 years of age): Headache treatment: If you get a headache, take 1 tablet with a full glass of water. The dose can be repeated if necessary after 4-6 hours from taking the first dose. For intense headache, take 2 tablets at once, if necessary, take another 2 tablets 4-6 hours after taking the first dose. Do not use for longer than 4 days without consulting your doctor. Migraine treatment: If you get migraine symptoms or aura, take 2 tablets with a glass of water, the dose can be repeated every 4-6 hours, if necessary. In the case of migraine, do not use for longer than 3 days without consulting your doctor. Maximum daily dose (for headache and migraine treatment): 6 tablets (1500 mg acetylsalicylic acid, 1500 mg paracetamol and 390 mg caffeine), do not exceed the recommended daily dose. Long-term use of the drug without medical supervision may be harmful to health. The lowest possible effective dose of the drug should be used for the shortest possible time. Use in children and adolescents: do not use under 18 years of age. Elderly: there is no need to change the dosage, only in the case of people with low weight the dosage should be discussed with a doctor. People with kidney and/or liver disorders: consult a doctor, do not use in people with severe kidney or liver failure. If after 3 days in the treatment of migraine and 4 days in the treatment of headache there has been no improvement or the condition has worsened, consult a doctor.

Producer:USP health