• Pork pancreas powder 319.1-414.4 mg

• Simeticon Emulsion
• triethyl citrate
• Methacrylic acid ethyl acrylate copolymer (1:1) dispersion 30%
• Printing ink black
• Printing ink black
• gelatin
• water, purified
• Sodium Lauryl Sulfate
• Polysorbate 80
• titanium dioxide
• titanium dioxide
• talc

Digestive enzymes in indigestion, COTAZYM 40,000 capsules indication

• The medicine is a mixture of digestive enzymes obtained from pig pancreas (pancreatic enzymes).
• The drug is used to replace digestive enzymes in digestive disorders (maldigestion) due to insufficient or missing function of the pancreas (exocrine pancreatic insufficiency).
• If you do not feel better or if you feel worse after a few days, contact your doctor.

dosage Digestive enzymes in indigestion, COTAZYM 40,000 capsules

• Always take this medicine exactly as described or as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
• The treatment is aimed at achieving or maintaining a normal body weight and normalizing the frequency and consistency of bowel movements.
• The dosage always depends on the severity of the pancreatic disease. A lipase content per meal of 20,000 - 40,000 Ph.Eur. units is recommended as a general guideline.
• Unless otherwise prescribed by the doctor, the usual dose is:
  • 1 hard capsule per meal (equivalent to 40,000 Ph.Eur. units of lipase per meal).
• The required dose can also be higher. The dose should only be increased under medical supervision and aimed at improving the symptoms (e.g. excretion of stool fat, abdominal pain).
• A daily enzyme dose of 15,000 - 20,000 units of lipase per kg of body weight should not be exceeded.

• How long should you take the medicine?
  • The duration of the application depends on the course of the disease and is determined by the doctor.
  • Do not take the medicine for more than a few days without medical or dental advice.
• Please talk to your doctor or pharmacist if you have the impression that the effect is too strong or too weak.

• If you take more than you should
  • Overdoses and intoxications with pancreas powder from pigs are not known.
  • For dosing in patients with cystic fibrosis, see the "Side Effects" category.

• If you forget to take a dose
  • Do not take a double dose to make up for a forgotten dose.

• If you stop taking it
  • If the treatment is discontinued, the recurrence of digestive disorders can be expected, which can manifest themselves, for example, in pain and diarrhoea.
  • Please talk to your doctor or pharmacist before stopping therapy or changing the preparation.

• If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Digestive enzymes in indigestion, COTAZYM 40,000 capsules way

• Do not take capsules lying down.
• Take the medicine whole with plenty of liquid (water, juice) during meals. Please ensure that you swallow the preparation without chewing, as chewing the drug can reduce its effectiveness and the enzymes it contains can damage the mucous membrane there when they are released in the oral cavity. You should drink plenty of fluids (water or juice).

side Digestive enzymes in indigestion, COTAZYM 40,000 capsules effects

• Like all medicines, this medicine can cause side effects, although not everybody gets them.
• The evaluation of side effects is based on the following frequency information:
  • Very common: affects more than 1 in 10 people
  • Common: affects 1 to 10 users in 100
  • Uncommon: affects 1 to 10 users in 1000
  • Rare: affects 1 to 10 users in 10,000
  • Very rare: affects less than 1 in 10,000 people
  • Not known: frequency cannot be estimated from the available data
• Significant side effects or signs to look out for and actions to take if affected.
  • If you are affected by any of the side effects listed below, stop taking the medicine and contact your doctor as soon as possible.
  • Very rarely, side effects after taking pancreas powder have been described as follows:
  • Skin and subcutaneous tissue disorders
    • Irritation in the area of ​​the anus
    • Allergic skin symptoms such as itching (pruritus), reddening of the skin (erythema), skin rash (exanthema), hives (urticaria)
  • Respiratory, upper and lower chest disorders
    • spasms of the bronchial muscles (bronchospasm)
    • asthma
    • shortness of breath (dyspnoea)
  • Diseases of the gastrointestinal tract:
    • Gastrointestinal intolerance such as pressure, heartburn, pain, feeling of fullness, flatulence (meteorism), nausea, nausea
    • Allergic reactions of the digestive tract
• Additional side effects in children and newborns
  • Diseases of the gastrointestinal tract
    • Inflammation of the lining of the mouth (stomatitis) in children
    • Bleeding in the gastrointestinal tract (newborns)
• After administration of high doses of pancreatin preparations, the formation of narrowing of the ileum/appendix region and the ascending sections of the large intestine (colon ascendens) has been described in individual cases in patients with cystic fibrosis, a congenital metabolic disorder. These narrowings can sometimes lead to an intestinal blockage.
• In patients with cystic fibrosis, increased uric acid excretion in the urine can occur, especially when taking high doses of pancreas powder. Therefore, urinary uric acid excretion should be monitored in these patients to avoid the formation of uric acid stones.
• Please tell your doctor or pharmacist if any of the listed side effects gets serious, or if you notice any side effects that are not listed.
• If you get any side effects, talk to your doctor or pharmacist. This also applies to side effects that are not specified.

Digestive enzymes in indigestion, COTAZYM 40,000 capsules interactions

• Taking with other medicines
  • Tell your doctor or pharmacist if you are taking/using, have recently taken/used or might take/use any other medicines.
  • The effect of the drugs or groups of preparations listed below can be influenced if they are treated with this preparation at the same time:
    • The effectiveness of pancreas powder can be reduced by the simultaneous intake of calcium or magnesium antacids (medicines against acidification of the stomach).
    • Although the connections z. Currently not yet elucidated, iron deficiency has often been described with long-term use of pancreas powder in patients with cystic fibrosis. Iron deficiency can be a cause of anemia. If you experience symptoms of anemia, such as B. Weakness and weakness, please inform your doctor.
    • Pancreas powder also contains carbohydrate-splitting enzymes. If this medicine is taken at the same time as certain blood-sugar-lowering medicines (glucosidase inhibitors such as acarbose and miglitol), the antidiabetic effectiveness of these medicines may be reduced. To avoid these interactions, a staggered intake is recommended.
    • Pancreas powder impedes the absorption of folic acid. Patients with pancreatic insufficiency should be carefully monitored for their folic acid status, particularly if they are taking pancreatic enzymes with bicarbonate (or with cimetidine).

Contraindications

• This medicine must not be taken
  • if you are allergic to pork pancreas powder, pork meat or any of the other ingredients of this medicine.
  • if you suffer from acute inflammation of the pancreas or flare-ups of chronic inflammation of the pancreas. On the other hand, taking the drug during the dietary build-up phase when an acute flare-up of inflammation subsides can make sense if a digestive disorder still or continues to exist.

pregnancy and breast feeding period

• If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
• You may take the medicine if you are pregnant or breastfeeding after consulting your doctor.

patient Digestive enzymes in indigestion, COTAZYM 40,000 capsules notes

• Warnings and Precautions
  • Please talk to your doctor or pharmacist before taking this medicine.
  • It contains active enzymes which, when released in the oral cavity, e.g. B. by chewing, can lead to mucosal damage (e.g. ulceration of the oral mucosa). It is therefore important to ensure that the preparation is swallowed whole.
  • If you suffer from cystic fibrosis, a congenital metabolic disorder, and are therefore given high doses of pancreas powder from pigs, there is the possibility that narrowing of the intestine (strictures) will form in certain parts of the small and large intestine. These narrowings can sometimes lead to an intestinal blockage. The following symptoms can indicate an intestinal obstruction: nausea and vomiting, flatulence with stool and wind retention, (severe) colicky pain, belching, later possibly vomiting faeces (so-called Miserere). If you experience any of these symptoms, you must seek medical attention immediately.
  • If you suffer from diabetes mellitus and are therefore taking blood sugar-lowering drugs that belong to the group of glucosidase inhibitors, then these drugs should not be taken at the same time as this preparation, but rather at different times.

• Driving and using machines:
  • There are no special precautions required.