ACIMETHIN film-coated tablets, methionine, urinary tract infections, urinary acidifiers
Acimethine film-coated tablets
Active ingredient: methionine
As a urinary acidifying substance with bacteriostatic effect in urinary tract infections, also for recurrence prevention in patients with neurogenic bladder dysfunction, to optimize the effect of antibiotics with optimum effect in acidic urine (pH 4-6): e.g. ampicillin, carbenicillin, sulfonamides, nalidixic acid, nitrofurantoin; to avoid the formation of new stones in phosphate stones (struvite, carbonate apatite, brushite)
As a urinary acidifying substance with a bacteriostatic effect in urinary tract infections.
active methionine, ACIMETHIN, urinary tract infections, urinary acidifiers ingredients
- 500 mg methionine
ACIMETHIN, urinary tract infections, methionine, urinary acidifiers excipients
- Povidone K30
- Magnesium stearate (vegetable)
- Silica, colloidal
- Carboxymethyl Starch, Sodium Type A
- cellulose, microcrystalline
- Macrogol 6000
- Butyl methacrylate copolymer, basic
- titanium dioxide
- ferric oxide
Indication/ ACIMETHIN, methionine, urinary tract infections, urinary acidifiers Application
- The drug is a physiological urological drug.
It is applied
as a urinary acidifier
- with bacteriostatic effect in urinary tract infections, also for prevention in patients with neurogenic bladder dysfunction
to optimize the effect of antibiotics with optimum effect in acidic urine (pH 4-6):
- e.g. B. ampicillin, carbenicillin, sulfonamides, nalidixic acid, nitrofurantoin
- to avoid the formation of new stones in phosphate stones (struvite, carbonate apatite, brushite).
- as a urinary acidifier
ACIMETHIN, methionine, urinary tract infections, urinary acidifiers dosage
- Always take this medicine exactly as described here or as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
Unless otherwise prescribed by the doctor, the recommended dose is
- In general, 1-2 film-coated tablets 3 times a day are sufficient. In order to achieve rapid urinary acidification, it makes sense to start the therapy with 2 film-coated tablets 3 times a day.
- In special cases and on doctor's orders, higher doses can be taken by patients who are not at risk of acidosis.
- A pH value of the urine of less than pH 6 is therapeutically aimed at. It must be taken into account that the effect can only occur after 5 - 6 days.
- There are no adequate studies on use in children.
- The drug should therefore not be used in children under 12 years of age.
duration of use
- The duration of use is determined by the doctor and depends solely on the therapeutic need.
If you take more than you should
- Methionine, the drug's active ingredient, is one of the amino acids that the human body cannot produce itself, but which it needs to build protein. Many foods contain methionine naturally.
- Intoxications (overdose symptoms) have not occurred so far.
If you forget to take a dose
- Do not take a double dose to make up for a forgotten dose.
- If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
ACIMETHIN, urinary tract infections, urinary acidifiers way, methionine
- The film-coated tablets are swallowed whole with some liquid before meals.
- Like all medicines, this medicine can cause side effects, although not everybody gets them.
- In patients at risk of acidosis, shifts in the blood pH value into the acidic range are possible.
- Taking the drug can cause vomiting, nausea, diarrhea, drowsiness, and irritability.
- If you get any side effects, talk to your doctor or pharmacist. This also applies to side effects that are not specified.
Taking with other medicines
- Tell your doctor or pharmacist if you are taking/using, have recently taken/used or might take/use any other medicines.
- With the simultaneous administration of active substances (e.g. ampicillin, carbenicillin, sulfonamides, nitrofurantoin and nalidixic acid), which are reabsorbed to a greater extent due to the acidification of the urine in the kidneys, the effect can be increased by prolonging the plasma half-life.
- Concomitant administration of levodopa and methionine can lead to a worsening of the effectiveness of levodopa in patients with Parkinson's disease. Increased dosage of methionine should be avoided in these patients.
The drug must not be taken
- if you are allergic to methionine or any of the other ingredients of this medicine
- in homocysteinuria (congenital metabolic disease)
- for uric acid and cystine stones (metabolic products)
- in case of renal insufficiency (limited renal function)
- in oxalosis (increased deposition of calcium oxalate crystals in kidney tissues and/or other organs)
- with methionine adenosyltransferase deficiency (metabolic disease)
- in metabolic (e.g. renal tubular) acidosis (blood acidification)
- in infants.
pregnancy and breast feeding period
- If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
- There are insufficient data on the use of methionine during pregnancy and lactation. Pregnant and breastfeeding women should only take the medicine after a careful benefit-risk assessment by their doctor.
patient methionine, ACIMETHIN, urinary tract infections, urinary acidifiers notes
Warnings and Precautions
- Please talk to your doctor or pharmacist before taking this medicine.
- Because of the risk of synthesis of neurotoxic mercaptans in bacterial metabolism, patients with liver dysfunction or hepatogenic encephalopathy (brain changes caused by liver disease) should not take methionine.
What precautions should be taken?
- If there is a deficiency in folic acid, vitamin B2, B6 and/or B12, treatment with methionine can lead to an increase in the homocysteine level. An increased occurrence of homocysteine in the blood can be regarded as an independent risk factor for the changes in the wall of the blood vessels that lead to "calcification". With long-term use of the drug, it is therefore important to ensure an adequate supply of folic acid and B vitamins through the diet supplementary income.
- The homocysteine plasma level can be increased under a hypothyroid metabolic situation (underactive thyroid gland). Thyroid function should therefore be checked prior to treatment with methionine.
- Exposure to methionine can lead to increased excretion of calcium in the urine (hypercalcuria). In the case of long-term treatment, regular monitoring of the mineral balance is therefore important.
- In patients at risk of acidosis, long-term treatment with the drug should be carried out with regular monitoring of the acid-base balance in the blood.
For medicines: Read the leaflet on the risks and side effects and ask your doctor or pharmacist.