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ACIMOL 500 mg avoid phosphate stones

Dr. Pfleger Arzneimittel GmbH

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ACIMOL 500 mg avoid phosphate stones

Acimol ® 500 mg film-

coated tablets App .: For urinary acidification with the therapeutic goal: Optimizing the effect of antibiotics with optimum effect in acidic urine, avoiding the formation of new stones in phosphate stones, inhibiting the growth of bacteria.

For avoid phosphate stones information on risks and side effects, read the package insert and ask your doctor or pharmacist.

Active avoid phosphate stones ingredients

  • 500 mg methionine

Auxiliary avoid phosphate stones materials

  • Cellulose, microcrystalline
  • Croscarmellose sodium
  • Hypromellose
  • Macrogol 6000
  • Magnesium stearate (vegetable)
  • Poly (ethyl acrylate-co-methyl methacrylate) (2: 1)
  • Silicon dioxide, finely divided
  • Corn starch, pre-gelatinized
  • talc
  • Titanium dioxide

Indication / application

  • The medicine is a urological agent.
  • It is applied
    • For urinary acidification with the therapeutic goal:
      • Optimization of the effect of antibiotics with optimum effect in acidic urine (pH 4 - 6): z. B. ampicillin, carbenicillin, nalidixic acid, nitrofurans.
      • Avoiding the formation of new stones with phosphate stones (struvite, carbonate apatite, brushite).
      • Inhibition of bacterial growth.


  • Always take the medicine exactly as directed. Please ask your doctor or pharmacist if you are not sure.
    • Unless otherwise prescribed by your doctor, the usual dose is:
      • 1 - 2 tablets 3 times a day (equivalent to 0.5 - 1 g methionine 3 times a day).
      • In patients who are not at risk of acidosis, the dosage can be increased to 10 g / day in special cases.
      • The therapeutic aim is to have a urine pH of less than 6. It must be taken into account that the drug can only take effect after 5 - 6 days.


  • Duration of application
    • The duration of use depends solely on the therapeutic necessity.
    • Please talk to your doctor if you have the impression that the effect of the drug is too strong or too weak.


  • If you take more than you should
    • Cases of overdose are not yet known.


  • If you forget to take a dose
    • If you have forgotten to take a dose, do not take it up, but continue with the next dose as described in the dosage instructions.


  • If you have any further questions on the use of the medicinal product, ask your doctor or pharmacist.


  • To take.
  • Please take the film-coated tablets with sufficient liquid (e.g. a glass of water).

Side effects

  • Like all medicines, the preparation can cause side effects, although not everybody gets them. When evaluating side effects, the following frequencies are usually used as a basis:
    • Very often:
      • More than 1 in 10 people treated
    • Often:
      • Less than 1 in 10 but more than 1 in 100 patients
    • Occasionally:
      • Less than 1 in 100 but more than 1 in 1000 people treated
    • Rarely:
      • Less than 1 in 1000 but more than 1 in 10,000 people treated
    • Very rare:
      • Less than 1 in 10,000 people, including isolated cases
  • Psychiatric illness
    • Irritability.
  • Nervous system disorders
    • Sleepiness.
  • Gastrointestinal disorders
    • Vomiting, nausea.
  • Investigations
    • In patients at risk of acidosis, the blood pH value may shift to the acidic range.
  • If you get any side effects, talk to your doctor or pharmacist. This also applies to side effects that are not specified.


  • When taking with other medicines
    • Please tell your doctor or pharmacist if you are taking / using or have recently taken / used any other medicines, including medicines obtained without a prescription.
    • The medicine can make L-dopa less effective in patients with Parkinson's disease. Increased methionine doses should be avoided in these patients.
    • The film-coated tablets can reduce the effects of active ingredients such as B. Increase penicillins, sulfonamides and nalidixic acid.
    • Please note that this information can also apply to recently used drugs.


  • The medicine must not be taken
    • if you are hypersensitive to the active ingredient or any of the other ingredients.
    • with congenital metabolic disease (homocysteinuria)
    • for uric acid and cystine stones
    • with renal insufficiency
    • with oxalosis (increased deposition of calcium oxalate crystals in kidney tissue and / or other organs)
    • in the case of methionine adenosyl transferase deficiency
    • in metabolic and renal tubular acidosis
    • in infants.

pregnancy and breast feeding period

  • There are insufficient data on the use of methionine during pregnancy and lactation. Pregnant and breastfeeding women should only take the drug after a careful risk-benefit assessment by the doctor.

Patient information

  • Take special care when taking it
    • Because of the risk of the synthesis of neurotoxic mercaptans in the bacterial metabolism, methionine should not be administered to patients with hepatic insufficiency or hepatogenic encephalopathy.
    • If there is a deficiency in folic acid, vitamins B 2 , B 6 and / or B 12 , methionine treatment can lead to an increase in the homocysteine ​​blood level. With long-term use of the film-coated tablets, it is therefore important to ensure a diet rich in folic acid and vitamin B.
    • In the context of an underactive thyroid, the homocysteine ​​blood level can be increased. Thyroid function should therefore be checked before treatment with methionine.
    • Treatment with methionine may increase the excretion of calcium in the urine. In the case of long-term use of the film-coated tablets, regular control of the mineral balance should therefore be ensured.
    • In patients at risk of acidosis, long-term treatment with methionine should be carried out with regular monitoring of the acid-base balance in the blood.
    • children
      • There is insufficient research into the use of this medicine in children. The film-coated tablets should therefore not be used in children under 12 years of age.


  • Driving and using machines
    • No known effects.