Caffeine, chronic fatigue syndrome, PERCOFFEDRINOL N

Aristo Pharma GmbH

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Caffeine, chronic fatigue syndrome, PERCOFFEDRINOL N 50 mg tablets

Percoffedrinol ® N Tablets

Active ingredient: caffeine.


Area of ​​Caffeine, chronic fatigue syndrome, PERCOFFEDRINOL N application: 

For the short-term elimination of signs of fatigue.

For Caffeine, chronic fatigue syndrome, PERCOFFEDRINOL N risks and side effects, read the leaflet and ask your doctor or pharmacist. (as of February 2012).

Aristo Pharma, Wallenroder Str. 8-10,
13435 Berlin


Areas of Caffeine, chronic fatigue syndrome, PERCOFFEDRINOL N application:

- Fatigue, for short-term treatment Instructions for

use Caffeine, chronic fatigue syndrome, PERCOFFEDRINOL N:

The total dose should not be exceeded without consulting a doctor or pharmacist .

Type of application?
Take the medicine with liquid (e.g. 1 glass of water).

Duration of use?
You should not use the medicine for long periods of time without medical advice. You should see your doctor if you have persistent or recurring symptoms.

Overdosing can cause seizures, among other things. If you suspect an overdose, contact a doctor immediately.

Forgot to take?
Continue taking it as normal (i.e. not double the amount) at the next prescribed time.

In general, pay attention to a conscientious dosage, especially for babies, small children and the elderly. If in doubt, ask your doctor or pharmacist about any effects or precautions.

A dosage prescribed by the doctor may deviate from the information on the package leaflet. Therefore, since the doctor adjusts them individually, you should use the medicine according to his instructions.

mode of action Caffeine, chronic fatigue syndrome, PERCOFFEDRINOL N:

How does the ingredient of the medicine work?

The active ingredient acts primarily on the cerebral cortex. Due to its stimulating effect, it temporarily eliminates the signs of tiredness in tired people and increases performance. In addition, it causes a narrowing of the cerebral vessels, which has a beneficial effect on headaches and migraines. Taken together with painkillers, their pain-relieving effect should be supported.

Caffeine, chronic fatigue syndrome, PERCOFFEDRINOL N Contraindications:

What speaks against an application?

- Hypersensitivity to the ingredients

Under certain circumstances - talk to your doctor or pharmacist about this:
- Cardiac arrhythmias
- Pulse acceleration
- Liver cirrhosis (damage to liver tissue)
- Hyperthyroidism
- Anxiety

What age group to consider?
- Children and adolescents under 18 years of age: There are no dosage information for this age group.

What about pregnancy and lactation?
- Pregnancy: consult your doctor. Various considerations play a role in whether and how the drug can be used during pregnancy.
- Breast-feeding: consult your doctor or pharmacist. He will examine your particular starting position and advise you accordingly as to whether and how you can continue breastfeeding.

If you have been prescribed the drug despite a contraindication, talk to your doctor or pharmacist. The therapeutic benefit can be higher than the risk that the use entails in the event of a contraindication.

Side effects:
What side effects can occur?

- Gastrointestinal complaints
- Headaches
- Insomnia
- Nervousness
- Inner restlessness
- Irritability
- Trembling
- Strange (paradoxical) reactions, such as:
- Tiredness
- Accelerated pulse
- Muscle pain

If you notice any changes in your condition or changes during treatment, contact your doctor or pharmacist.

For the information at this point, side effects are primarily taken into account that occur in at least one in 1,000 patients treated.

Important Caffeine, chronic fatigue syndrome, PERCOFFEDRINOL N information:
What should you consider?
- There may be medicines with which interactions occur. You should therefore generally tell your doctor or pharmacist about any other medicine you are already using before starting treatment with a new medicine. This also applies to medicines that you buy yourself, use only occasionally or have been using for some time.

For medicines: Read the leaflet on the risks and side effects and ask your doctor or pharmacist.

For the short-term elimination of signs of fatigue.

active Caffeine, chronic fatigue syndrome, PERCOFFEDRINOL N ingredients

  • 50 mg of caffeine

Caffeine, chronic fatigue syndrome, PERCOFFEDRINOL N excipients

  • Silica, colloidal
  • cellulose powder
  • cellulose, microcrystalline
  • Magnesium stearate (vegetable)
  • potato starch


  • The preparation is a stimulant (analeptic) / xanthine derivative.
  • The drug is used for the short-term elimination of signs of fatigue.
  • A notice:
    • Not all signs of fatigue require medication.


  • Always take this medicine exactly as described or as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
  • Unless otherwise prescribed by the doctor, the usual dose is:
    • Take 2 to 4 tablets of the preparation daily (one tablet is often sufficient as a single dose).


  • Type and duration of use
    • For a faster effect, take the tablets on an empty stomach, crushed and with water. The effect of one tablet lasts for several hours. It is therefore advisable to take the preparation during the day so that the night sleep is not disturbed.
    • Please take the tablets as needed and not as a habit over a long period of time.
    • Please talk to your doctor or pharmacist if you have the impression that the effect of the preparation is too strong or too weak.


  • If you take more of the medicine than you should
    • Signs of an overdose are central nervous symptoms (e.g. restlessness, excitement, fear, anxiety, tremors), seizures, life-threatening cardiovascular complications (e.g. tachycardia, cardiac arrhythmia, anxiety/pain in the heart area), but also nausea and vomiting.
    • If you experience these signs, contact a doctor immediately. If necessary, first aid measures are to be initiated; if unconscious, keep the airways clear.


  • If you have any further questions on the use of the medicine, ask your doctor or pharmacist.


  • For a faster effect, take the tablets on an empty stomach, crushed and with water. The effect of one tablet lasts for several hours. It is therefore advisable to take the preparation during the day so that the night sleep is not disturbed.

side effects

  • Like all medicines, this medicine can cause side effects, although not everybody gets them.
  • Possible side effects:
    • The occurrence of side effects depends on the individual sensitivity to caffeine and the daily consumption of caffeine-containing beverages.
    • Even low doses can lead to insomnia, inner restlessness, tachycardia and gastrointestinal problems. Irritability, headaches and increased physiological tremors (muscle tremors) can also occur in less sensitive people at doses of more than 200 mg (corresponding to 4 tablets of the preparation).
    • Prolonged use of caffeine, especially medium to high doses, leads to the development of tolerance to most effects, but also to side effects.
    • Headaches, tiredness, muscle pain, nervousness and vegetative symptoms can occur if the drug is stopped abruptly after long-term use of higher doses.
    • Allergic reactions have been described in individual cases.
    • If you get any side effects, talk to your doctor or pharmacist. This also applies to side effects that are not specified.
  • What countermeasures should be taken in the event of side effects?
    • Please refrain from further intake of the preparation and any intake of caffeinated beverages or stimulants. Please contact your doctor.


  • Taking the preparation together with other medicines
    • Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
    • Caffeine has an antagonistic (opposite) effect to the sedative effects of numerous substances, such as e.g. B. Barbiturates (sedatives), antihistamines (medicines against allergies) etc.
    • Caffeine acts synergistically (in the same direction/increasingly) compared to the tachycardic effects of e.g. B. Sympathomimetics (hypertensive agents), thyroxine (thyroid hormone) etc.
    • In the case of broad-spectrum substances, the interactions may vary in detail and be unpredictable (e.g. sedatives of the benzodiazepine type).
    • When 50 mg of caffeine is administered at the same time as paracetamol or acetylsalicylic acid (certain painkillers and fever relievers), a relative analgesic (pain-relieving) potency of between 1.3 and 1.7 has been found in various studies. This can lead to a corresponding saving of the analgesic substance.
    • The promoting influence of caffeine on the absorption of ergotamine and dihydroergotamine has not been adequately proven experimentally.
    • Oral contraceptives ("birth control pills"), cimetidine (agent against gastrointestinal ulcers) and disulfiram (alcohol cessation aid) reduce the breakdown of caffeine in the liver, while barbiturates (tranquilizers) and smoking accelerate it.
    • The excretion of theophylline (asthma drug) is reduced by caffeine.
    • Concurrent administration of quinolonecarboxylic acid-type gyrase inhibitors (antibacterial agents) may delay the elimination of caffeine and its breakdown product paraxanthine.
    • Caffeine increases the potential for dependency on substances of the ephedrine type (centrally acting sympathomimetic). There is no evidence that caffeine increases the potential for dependence on analgesics (painkillers) such as acetylsalicylic acid or paracetamol.
    • Even if it can be assumed on the basis of theoretical considerations, an independent abuse potential of caffeine in combination with analgesics is not proven based on the current knowledge.
    • Please note that this information may also apply to recently used medicines.
  • Taking the preparation with food and drink
    • Please note that when using the preparation and drinking caffeine-containing beverages at the same time, 50 to 100 mg of caffeine are additionally absorbed with a cup of coffee/black tea and around 20 mg of caffeine with a glass of cola.


  • The preparation must not be taken
    • if you are allergic to caffeine or any of the other ingredients of this medicine.

pregnancy and breast feeding period

  • pregnancy
    • If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
    • High doses of caffeine during pregnancy may increase the risk of miscarriage (spontaneous abortion) and premature birth.
  • lactation
    • The infant's well-being and behavior can be affected during breastfeeding. In the first months of life, the ability to excrete caffeine is about 10 times lower than that of adults. Only after 4 to 8 months does the ability to excrete caffeine approach that of adults.
  • The indicated dosages should not be exceeded during pregnancy and lactation.

patient notes

  • Warnings and Precautions
    • Please talk to your doctor or pharmacist before taking this medicine.
    • Patients with cardiac arrhythmias (risk of aggravation), patients with liver cirrhosis (risk of reduced caffeine breakdown and thus caffeine accumulation in the body), patients with hyperthyroidism (risk of aggravation of caffeine side effects) and patients suffering from anxiety (risk of reinforcement) should only use caffeine in low doses (approx. 100 mg; corresponding to 2 tablets of the preparation) or under medical prescription.
    • You should not overestimate the ability to compensate for reduced performance through the use of caffeine. Caffeine in no way compensates for the performance impaired by alcohol, in individual cases there is a risk of accelerated absorption of alcohol into the blood.
    • Prolonged abuse of high doses is warned because of the possible occurrence of symptoms of acute caffeine intoxication.
  • children
    • Children are most likely to experience side effects from caffeine.


  • Ability to drive and use machines
    • When used as intended, the preparation does not impair the ability to drive or operate machines.