CALCIUM ACETATE NEFRO 500 mg, calcium ion

MEDICE Arzneimittel Pütter GmbH&Co.KG

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CALCIUM ACETATE NEFRO 500 mg film-coated tablets, calcium ion

Calcium acetate Nefro 500 mg film-coated tablets
Active ingredient: calcium acetate

CALCIUM ACETATE NEFRO 500 mg, calcium ion Areas of application:

Calcium acetate Nefro500mg is used to reduce phosphate in the case of elevated serum phosphate levels in patients with chronic kidney failure on dialysis treatment

Active ingredient: calcium ion

A mineral supplement used to bind phosphate found in food.

  • 500 mg calcium diacetate

CALCIUM ACETATE NEFRO 500 mg, calcium ion excipients

  • cellulose, microcrystalline
  • Povidone K30
  • crospovidone
  • Magnesium stearate (vegetable)
  • 2.4 mg sucrose
  • hypromellose
  • Macrogol 6000
  • talc

CALCIUM ACETATE NEFRO 500 mg, calcium ion Indication/Application

  • The drug is a mineral supplement used to bind phosphate contained in food. This reduces the amount of phosphate that is absorbed into the body.
  • The medicine is used to treat and prevent high levels of phosphate in patients on dialysis for severe kidney disease.

CALCIUM ACETATE NEFRO 500 mg, calcium ion dosage

  • Always take the medicine exactly as described or as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
  • The recommended dose is:
    • adult
      • Unless otherwise prescribed by your doctor, you should start taking 2 film-coated tablets three times a day.
      • The dosage depends on the level of phosphate in your blood. It should be checked regularly. If more calcium acetate is required to lower your phosphate levels, the dosage should be increased gradually.
      • The usual dose is 2 film-coated tablets four times a day or 3 film-coated tablets three times a day. The maximum dose of 9 tablets per day should not be exceeded.
      • The doctor treating you decides on the dosage and duration of use.
      • The treatment is a long-term therapy and requires regular medical supervision.
    • Children and adolescents (under 18 years)
      • There are no data on use in children and adolescents under 18 years of age. The use of the preparation can therefore not be recommended for these patients.


  • If you take more than you should
    • Calcium overdose can lead to high levels of calcium in the blood (hypercalcaemia) and calcification of tissues. Please contact your doctor immediately if you accidentally take too many tablets. Symptoms of overdose may include but are not limited to muscle weakness, abdominal pain, constipation, nausea, vomiting, excessive thirst, abnormal heart rhythm, and loss of consciousness.


  • If you forget to take a dose:
    • Do not take a double dose to make up for a forgotten dose.


  • If you stop taking it
    • Do not stop taking the medicine without consulting your doctor.


  • If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

CALCIUM ACETATE NEFRO 500 mg, calcium ion way

  • The film-coated tablets should be swallowed whole with some liquid. Please only take the film-coated tablets with meals so that the preparation can have the best possible effect.

side effects

  • Like all medicines, this medicine can cause side effects, although not everybody gets them.
  • Some of the side effects can be serious. If you notice any of the following side effects, please see a doctor immediately:
    • Uncommon (may affect up to 1 in 100 people)
      • Severe hypercalcaemia (high blood calcium levels) may occur. The symptoms include: disturbances of consciousness, such as drowsiness, disorientation and drowsiness, in extreme cases also coma, as well as impaired kidney function. Severe hypercalcaemia is accompanied by excessive thirst, excessive urination, cardiac arrhythmia and calcium deposits in the kidneys.
      • Long-term treatment with calcium acetate in high doses is associated with hypercalcaemia and extraosseous calcifications (deposits of calcium outside the bones) in the heart and vascular valves of blood vessels and in tissues, as well as with calciphylaxis (calcification of the blood vessel walls and subcutaneous fatty tissue with functional impairment, inflammation and necrosis of the affected vessels and tissue as possible consequences). To avoid these problems it is recommended to keep the dosage of calcium acetate as low as possible and to adjust it to the serum calcium and serum phosphate levels.
    • Common (may affect up to 1 in 10 people)
      • Mild hypercalcaemia (elevated blood calcium levels) may develop. The signs of this are muscle weakness and abdominal pain. Belching, bloating, nausea, vomiting, constipation, and diarrhea may also occur.
  • If you get any side effects, talk to your doctor or pharmacist. This also applies to side effects that are not specified.

CALCIUM ACETATE NEFRO 500 mg, calcium ion interactions

  • Taking with other medicines
    • Tell your doctor or pharmacist if you are taking/using, have recently taken/used or might take/use any other medicines.
    • This is especially important if you are taking the following medicines:
      • Water tablets (thiazide diuretics such as bendroflumethiazide) or preparations containing vitamin D. In this case, your calcium level must be checked more frequently (e.g. weekly).
      • Medicines containing female sex hormones (oestrogens such as estradiol) or vitamin A.
      • Certain heart medications (cardioactive glycosides such as digoxin) as these may be affected by your calcium levels. There is an increased risk of cardiac arrhythmia occurring, so that regular ECG checks are required.
      • Medicinal products containing aluminum to counteract hyperacidity in the stomach (antacids), since taking them can lead to increased aluminum absorption.
    • Taking calcium acetate worsens the absorption and thus the effectiveness of some medicines. This applies to, among other things
      • certain antibiotics,
        • e.g. B. Tetracyclines (such as tetracycline, oxytetracycline, doxycycline)
        • some fluoroquinolones (such as ciprofloxacin, ofloxacin)
        • some cephalosporins (such as cefpodoxime, cefuroxime)
      • certain antifungal medicines (ketoconazole)
      • certain medicines for osteoporosis (bisphosphonates)
      • certain medicines used to treat high blood pressure, coronary artery disease and heart rhythm disorders (such as verapamil)
      • certain anticancer medicines (estramustine preparations)
      • certain medicines for incontinence (anticholinergics)
      • certain medicines for gallstones (ursodeoxycholic acid, chenodeoxycholic acid)
      • Medicines containing fluoride, zinc or iron
    • Take these medicines at least 3 hours before or after taking calcium acetate.
  • Take with food and drink
    • Please note that dairy products have a high calcium content and can therefore enhance the effects of calcium acetate. A liter of milk contains 1200 mg of calcium.



  • The medicine must not be taken
    • with increased calcium concentration in the blood (hypercalcaemia).
    • if you are allergic to calcium acetate or any of the other ingredients of this medicine.

pregnancy and breast feeding period

  • If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking/using this medicine.
  • There are no data on the use of the drug during pregnancy and lactation.
  • If you are pregnant or breastfeeding, you should only take the medicine on the express orders of your doctor and only under regular monitoring of the serum calcium level.

patient CALCIUM ACETATE NEFRO 500 mg, calcium ion notes

  • Warnings and Precautions
    • Please talk to your doctor or pharmacist before taking this medicine.
      • Your doctor may ask you to have a dietary consultation before taking this medicine. You will learn how much phosphate and calcium you take in through food and how you can keep the phosphate levels in a healthy range.
      • Your doctor adjusts the dose of the medicine based on the amount of phosphate that you get from food and that is removed by dialysis.
      • Regular monitoring of blood phosphate and calcium levels is necessary to determine the effectiveness of the treatment and to prevent high levels of calcium in the blood (hypercalcaemia). Monitoring should be done at least once a month.
      • If you take medicines containing vitamin D at the same time, there is an increased risk of an increased concentration of calcium in the blood (hypercalcaemia). The simultaneous use of preparations containing calcium and vitamin D must therefore be carried out under medical supervision.
      • Please ask your doctor about the signs of an increased calcium concentration in the blood (hypercalcaemia) so that you can recognize them at an early stage.
      • You should seek medical advice before taking calcium-containing medicines to combat hyperacidity of the stomach (antacids) in order to avoid an additional calcium load.
      • If you are taking certain medicines for the treatment of heart diseases (cardioactive glycosides) at the same time as taking calcium acetate, regular ECG examinations and additional checks of your calcium level should be carried out.


  • Ability to drive and use machines
    • This preparation has no influence on the ability to drive and use machines. However, a greatly increased concentration of calcium in the blood (hypercalcaemia) can lead to disturbances of consciousness such as drowsiness or weakness. Therefore, look out for signs of increased calcium levels before driving or operating machinery.

A mineral supplement used to bind phosphate found in food.