• 0.06 mg cholecalciferol

• Polyglycerol x oleate
• Olive oil, refined
• orange peel oil
• DL-α-tocopherol acetate

Cholecalciferol, Natural treatment for osteoporosis DEVIT dropsindication

• The medicine contains colecalciferol (vitamin D). There are few foods that contain vitamin D. It is also formed in the body when the skin is exposed to sunlight. Vitamin D supports the kidneys and intestines in absorbing calcium and helps build bones.
• The drops are applied:
  • For the prevention of rickets (calcification disorders of the growing skeleton) in premature babies, newborns and children
  • For the supportive treatment of osteoporosis (breakdown of bone tissue).

dosage Cholecalciferol, Natural treatment for osteoporosis DEVIT drops

• Always take this medicine exactly as described or as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
• The recommended dose is:
  • To prevent rickets in infants and young children:
    • Babies under 1 year: 6 drops daily (equivalent to 400 IU of vitamin D)
    • Small children over 1 year: 6 - 9 drops daily (equivalent to 400 - 600 IU of vitamin D)
  • To prevent rickets in premature babies:
    • The dosage is to be determined individually by the attending physician.
  • For the supportive treatment of osteoporosis:
    • 12 - 15 drops daily (equivalent to 800 - 1000 IU of vitamin D)

• If you take more than you should
  • Symptoms of an overdose
    • Ergocalciferol (vitamin D ₂ ) and colecalciferol (vitamin D ₃ ) only have a relatively narrow therapeutic index. In adults with normal parathyroid function, the threshold for vitamin D intoxication is between 40,000 and 100,000 IU per day for 1 to 2 months. Babies and young children can be sensitive to much lower doses. Therefore, a warning is given against taking vitamin D without medical supervision.
    • In the case of an overdose, in addition to an increase in phosphate in the blood and urine, hypercalcaemia syndrome (increased calcium concentration in the blood) occurs, which later also leads to calcium deposits in the tissues and especially in the kidneys (kidney stones and kidney calcification) and the vessels.
    • The symptoms of intoxication are not very characteristic and are expressed in nausea, vomiting, initially often diarrhea, later constipation (constipation), loss of appetite, fatigue, headache, muscle and joint pain, muscle weakness and persistent drowsiness, azotemia (increased nitrogen concentration in the blood), increased thirst and increased urge to urinate and in the final phase dehydration. Typical laboratory findings are hypercalcaemia (increased calcium concentration in the blood), hypercalciuria (increased calcium concentration in the urine) and increased serum values ​​for 25-hydroxycholecalciferol.
  • Therapeutic measures in case of overdose
    • In the event of an overdose, measures to treat the often long-lasting and potentially dangerous hypercalcaemia (increased calcium concentration in the blood) are required.
    • The first step is to stop taking the vitamin D preparation; normalization of hypercalcaemia (increased calcium concentration in the blood) as a result of vitamin D intoxication takes several weeks. Graded according to the extent of the hypercalcaemia (elevated calcium concentration in the blood), calcium-poor or calcium-free nutrition, copious fluid intake, increased urination with the drug furosemide and the administration of glucocorticoids (medicines to treat certain allergic diseases) and calcitonin (hormone to regulate the calcium concentration in the blood) are used.
    • With adequate kidney function, infusions with isotonic sodium chloride solution (3 to 6 l in 24 hours) with the addition of furosemide (medicine to increase urine excretion) and possibly also 15 mg/kg body weight (bw)/hour sodium edetate (medicine that absorbs calcium in the blood binds) quite reliably calcium-lowering under continuous calcium and ECG monitoring. In the case of reduced urine excretion, on the other hand, hemodialysis treatment (blood washing) with a calcium-free dialysate is indicated.
    • There is no specific antidote.
    • Please ask your doctor or pharmacist about the signs of a vitamin D overdose.

• If you forget to take a dose
  • Do not take a double dose to make up for a forgotten dose.

• If you stop taking it
  • If you stop taking it early, your symptoms may get worse or come back.

• If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Cholecalciferol, Natural treatment for osteoporosis DEVIT drops way

• The solution is administered or taken according to the dosage instructions.
• Adults take the solution in a teaspoon of liquid.

side effects

• Like all medicines, this medicine can cause side effects, although not everybody gets them.
  • The frequency of side effects is based on the following categories:
    • Very often more than 1 in 10 people treated
    • Often affects 1 to 10 users in 100
    • Uncommon: 1 to 10 users in 1,000
    • Rarely affects 1 to 10 users in 10,000
    • Very rarely affects less than 1 in 10,000 people
    • Not known Frequency cannot be estimated from the available data
• possible side effects
  • The side effects arise as a result of an overdose.
  • Depending on the dose and duration of treatment, severe and long-lasting hypercalcaemia (elevated calcium concentration in the blood) with its acute (cardiac arrhythmia, nausea, vomiting, psychological symptoms, disturbances of consciousness) and chronic (increased urination, increased thirst, loss of appetite, weight loss, kidney stone formation, kidney calcification, Calcification in tissues outside the bone) consequences occur.
  • Fatal courses have been described very rarely.
• If you get any side effects, talk to your doctor or pharmacist. This also applies to side effects that are not specified.

Cholecalciferol, Natural treatment for osteoporosis DEVIT drops interactions

• Taking with other medicines
  • Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
  • Phenytoin (medicines used to treat epilepsy) or barbiturates (medicines used to treat epilepsy and sleep disorders and for anaesthesia) can impair the effect of vitamin D.
  • Thiazide diuretics (drugs to increase urine output) can cause hypercalcaemia (high levels of calcium in the blood) by reducing calcium excretion via the kidneys. Calcium levels in the blood and urine should therefore be monitored during long-term treatment.
  • The simultaneous administration of glucocorticoids (medicines used to treat certain allergic diseases) can impair the effect of vitamin D.
  • The risk of an undesirable effect when taking cardiac glycosides (medicines to stimulate the functioning of the heart muscles) may increase as a result of an increase in blood calcium levels during treatment with vitamin D (risk of cardiac arrhythmia). They should therefore be monitored for ECG and blood and urine calcium levels. Please note that this also applies to medicines you have recently taken.

Contraindications

• The drops should not be taken
  • if you are allergic to colecalciferol or any of the other ingredients of this medicine
  • in case of hypercalcaemia (increased calcium level in the blood) and/or
  • Hypercalciuria (high levels of calcium in the urine)
  • in pseudohypoparathyroidism (disorder of the parathyroid hormone balance), since the vitamin D requirement can be reduced due to the phased normal vitamin D sensitivity, with the risk of a long-lasting overdose. For this purpose, more easily controllable active ingredients with vitamin D activity are available.
  • with a tendency to calcium-containing kidney stones
  • if the vitamin D level in the blood is increased (hypervitaminosis D)

pregnancy and breast feeding period

• If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
• pregnancy
  • During pregnancy, the drops should only be taken when clearly necessary and only in doses that are absolutely necessary to correct the deficiency. Overdoses of vitamin D during pregnancy must be avoided because prolonged hypercalcaemia (elevated levels of calcium in the blood) can lead to physical and mental disability and congenital heart and eye diseases in the child.
• lactation
  • Vitamin D and its metabolites pass into breast milk. An overdose in infants produced in this way has not been observed.

patient Cholecalciferol, Natural treatment for osteoporosis DEVIT drops notes

• Warnings and Precautions
  • Please talk to your doctor or pharmacist before taking the drops.
  • Special care is required when taking
    • if you have problems with the excretion of calcium and phosphate via the kidneys
    • during treatment with benzothiadiazine derivatives (medicines to promote urination)
    • if you are immobilized as there is a risk of hypercalcaemia (high blood calcium levels) and hypercalciuria (high urinary calcium levels). Blood and urine calcium levels should be monitored.
    • if you suffer from sarcoidosis, as there is a risk of increased conversion of vitamin D to its active form. Blood and urine calcium levels should be monitored.
  • In patients with renal impairment who are being treated, the effect on calcium and phosphate balance should be monitored.
  • If other medicines containing vitamin D are prescribed, the dose of vitamin D must be taken into account. Additional administrations of vitamin D or calcium should only be carried out under medical supervision. In such cases, calcium levels in the blood and urine must be monitored.
  • During long-term treatment, blood and urine calcium levels should be monitored regularly and renal function should be checked by measuring serum creatinine. This check is particularly important in elderly patients and during concomitant treatment with cardiac glycosides (medicines that stimulate the heart muscles) or diuretics (medicines that stimulate urination). In case of hypercalcaemia (increased calcium concentration in the blood) or signs of reduced kidney function, the dose must be reduced or the treatment interrupted. It is recommended to reduce the dose or interrupt treatment if the urinary calcium level exceeds 7.5 mmol/24 hours (300 mg/24 hours).

• Ability to drive and use machines
  • There are no special precautions required.