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Indications for use of the drug are: pains of various origin of weak or medium intensity (e.g. migraine, headaches, rheumatic, muscle, neuralgia, toothache); feverish conditions; symptomatic treatment of influenza and colds.
COFFEPIRINE neuralgia, toothache Composition of:
1 tabl. contains 450 mg acetylsalicylic acid and 50 mg caffeine.
COFFEPIRINE neuralgia, toothache Action:
The acetylsalicylic acid contained in the preparation works mainly by inhibiting the release and biosynthesis of prostaglandins, analgesic, antipyretic and anti-inflammatory. Reduces platelet aggregation by blocking the release of adenosine diphosphoric acid and thromboxane A2 from platelets. At doses above 1 g per day, it reduces blood clotting and has a fibrinolytic effect. Antipyretic and diaphoretic effect is strongly marked already at doses of 1-1.5 g / day (especially at elevated body temperature), anti-inflammatory effect is clearly marked after a few days of intake. It is absorbed quickly and almost completely from the digestive tract - mainly from the stomach, to a lesser extent from the intestines. The rate of absorption depends on the pH of the content. It binds to plasma albumin in 50-90%. It easily penetrates into the tissues and across the placental barrier and into breast milk. It is metabolized in the liver (mitochondria and endoplasmic reticulum) and in other tissues. It is excreted in 10% in the urine in unchanged form and in the form of metabolites (in 75% as salicyluric acid). T0.5 is 2-4 hours. Systematically used during pregnancy in the third trimester or for a long time - it has a negative effect on the fetus; during lactation - may cause metabolic acidosis in the fed infant (doses above 3 g / day in the mother). The caffeine contained in the preparation is well absorbed from the gastrointestinal tract, is metabolized in the liver, metabolites are excreted in the urine. It can have a stimulating effect on vegetative centers: respiratory, vasomotor and vagus nerve, endure tiredness.
Indications
Pain of various origins of mild or moderate intensity (e.g. migraine, headache, rheumatic, muscle, neuralgia, toothache); feverish conditions; symptomatic treatment of influenza and colds.
Contraindications
Hypersensitivity to the preparation ingredients. Active gastric and / or duodenal ulcer, gastrointestinal inflammation, hypersensitivity to salicylates, haemorrhagic diathesis and blood coagulation disorders, gout, severe renal or hepatic impairment; children under 12 years of age Use with caution in patients with decompensated circulatory insufficiency, hypertension (due to the content in the caffeine preparation), in asthma, in patients with nasal polyps, before surgery, when using contraceptive intrauterine devices and heavy menstrual bleeding. Only after consultation with the doctor can be used during pregnancy (temporary) and breastfeeding (emergency use does not require interruption of feeding). Due to the content of acetylsalicylic acid in the preparation, it is not recommended for children and adolescents under 12 years of age. in chickenpox and influenza, and in other feverish diseases in children and adolescents, indications for drug administration must be determined individually by the physician (when other painkillers are ineffective) - due to the possibility of life-threatening Reye syndrome & apos; a.
Dosage
Orally. Adults and children over 12 years of age: 1 table 2-6 times a day, not more often than every 4 hours. Do not use for a long time, do not take on an empty stomach. In emergency treatment, do not exceed 8 tablets. per day; for long-term treatment, the dose is determined by the doctor. Take tablets with plenty of liquid.