- The indications for use of the product Duphalac are chronic and habitual constipation and hepatic encephalopathy - the prevention and treatment of hepatic coma and state przedśpiączkowego.
15 ml of Duphalac contains the active ingredient: 10 g lactulose
and <1.65 g galactose <0.9 g of lactose and traces of other sugars.Indications: Constipation chronic and habitual Hepatic encephalopathy - the prevention and treatment of hepatic coma and state przedśpiączkowego . Action: The product contains the active substance Duphalac lactulose, which acts as a laxative.
In the large intestine, lactulose is degraded by the intestinal bacteria to low molecular weight organic acids, such as lactic acid and acetic acid. This leads to acidify the intestinal contents, which preparation contains the active substance DuphalacŽ lactulose, which acts as a laxative.
In the large intestine, lactulose is degraded by the intestinal bacteria to low molecular weight organic acids, such as lactic acid and acetic acid. This leads to acidify the intestinal contents, which stimulates the motility of the (contraction), and changes in osmotic pressure (download water into the intestinal lumen), which normalizes the stool consistency.
In the case of hepatic encephalopathy (PSE) on the background of the portal hypertension, lactulose causes a reduction of blood ammonia as follows:
'acidifying the contents of the large intestine inhibits the growth of spoilage bacteria protein, thus reducing the production of ammonia and other toxins' acidification of the gut content results in conversion of ammonia the ammonium ion, which is practically not absorbed from the intestine into the bloodstream. In addition, acidification of intestinal contents moves through the ammonia from the blood into the intestine and accelerate the excrement to the outside. These changes in the metabolism of ammonia, increase the tolerance of protein in the diet of patients with hepatic impairment.
Lactulose is degraded by bacteria in the large intestine low molecular weight fatty acids are not degraded in the stomach or intestine.
Dosage of constipation
The initial dose
Adults 30 ml per day
Children from 7 to 14 years old 15 ml per day
Children from 1 to 6 years with 10 ml per day
Infants 5 ml a day
After a few days, the dose should be reduced and adapted to the individual needs of the patient
The drug should be accepted orally once a day, preferably during breakfast.
Laxative effects can occur after a few days, due to the mechanism of action of lactulose.