Composition Efferalgan rectal 150mg x 10 pieces, fever treatment, fever in children:

1 suppository contains 150 mg Paracetamol

Action: drug with analgesic and antipyretic, mainly by inhibiting prostaglandin cyclooxygenase activity in the CNS well absorbed from the gastrointestinal tract, the maximum blood concentration reaches approximately 20-60 min., Penetrates into the body fluids and organs internal, approximately 25% bound to plasma proteins. T _0.5 is 2-3 h. It is metabolized in the liver, cause there microsomal enzyme induction; excreted in the urine as glucuronide and sulfate, and after coupling with cysteine. In patients with renal failure linked paracetamol accumulates in the blood. At high doses produced in the body of N-acetyl-p-benzoquinone responsible probably for causing liver damage.

Indications: Symptomatic treatment of pain and of fever.

Contraindications: Hypersensitivity to the drug (rare), congenital deficiency of G-6-PD and reductase methemoglobinowej .Caution should be exercised in patients with asthma who are allergic to aspirin, and in the case of repeated doses in patients with severe hepatic impairment. It should not be used in children under 3 months of age

Adverse reactions: There have been isolated cases of haematological disorders with long-term use (thrombocytopenia with symptoms of thrombocytopenic purpura), and allergic skin reactions (urticaria, erythema, pruritus, rash). Used in high doses or long-term may impair liver function.

Interaction: Paracetamol does not change the bleeding time and platelet aggregation in healthy subjects and patients with hemophilia. Used with drugs that inhibit decomposition of paracetamol in the liver (rifampicin, antiepileptics, some sleeping pills) increases the risk of liver damage, with lamotrigine or chloramphenicol - reduces their concentration in the blood. Cimetidine, metyrapone, probenecid, antipyrine, salicylamide, isoniazid, ranitidine, propranolol - prolong the half-life of paracetamol in the blood.

Dosage Efferalgan rectal 150mg x 10 pieces, fever treatment, fever in children:

In children under 3 months of age paracetamol can be used only at the express order of a physician. The recommended dose of rectally for children over 3 m.ż .: 10-15 mg / kg 4 times a day, in some cases every 4 h - the dose can be used for 3 days. Do not exceed a daily dose of 60 mg / kg Adults and children over 15 years of age600 mg 1-4 times a day. Do not exceed a dose of 3.0 g per day. Between doses should be a minimum distance of at least 4 h. In the case of severe renal impairment (creatinine clearance below 10 ml / min) interval between doses should be at least 8 h.