1 ml (20 drops) contains 1 mg dimetindenu maleate.
Operation: An antihistamine - histamine H1 receptor antagonist. This significantly reduces the excessive permeability of the capillaries associated with hypersensitivity reactions of the immediate type.Exerts przeciwkininowe and weak anticholinergic and sedative.Operation of the drug starts after 30-60 min after administration and is maintained for 8-12 h. The maximum concentration in the blood after administration of the solution occurs at about 2 h. Dimetindene binds approximately 90% to plasma proteins. It is metabolized in the liver and excreted in the bile and urine, mostly as metabolites. T 0.5after administration in solution is 6 hours.
Indications: fenistil drops are symptomatic treatment of allergic cutaneous diseases (urticaria, itching in atopic dermatitis, allergic contact dermatitis and eczema endogenous) and respiratory allergic diseases (allergic rhinitis), food allergy and drug-induced. Alleviation of itching in the course of infectious diseases (eg chicken pox), as well as the alleviation of symptoms after the bite of insects. Prophylactically to prevent allergic reactions occurring after anesthesia.
Contraindications: Hypersensitivity to dimetindene, or any of the excipients, newborns.
Precautions: Carefully apply infants to complete 12 months of age, patients with glaucoma or urinary retention associated with prostatic hyperplasia. pregnancy and breastfeeding pregnant used only when strictly reasonable indication (on the order of a physician.) Do not use fenistil drops during breastfeeding.
Undesirable effects: Occasionally, headache, dizziness, agitation or drowsiness, disorders of the gastrointestinal tract (such as nausea), dry mouth, hypersensitivity reactions (single cases of swelling of the tongue, skin rash, respiratory disorders, muscle cramps face and neck).
Interactions: fenistil drops can increase the effects of hypnotics, sedatives, alcohol. MAO inhibitors enhance the effects of anticholinergic antihistamines. Furthermore, in combination with MAO inhibitors, tricyclic antidepressants, or drugs cholinolitycznymi increases the risk of urinary retention, and an attack of glaucoma.
Dosage: Oral. Adults and children over 12 years of age 3 times daily for 20-40 fenistil drops (eg. 3-6 mg / day); patients prone to drowsiness administered 40 drops before bedtime and 20 drops during breakfast. Children: Infants from 2 months of age - 3 times a day 0.15-0.5 mg (ie. After 3-10 drops); children 2-3 years of age - 3 times a day 0.5-0.75 mg (ie. 10-15 drops); 4-12 years of age - 3 times a day 0,75-1,0 mg (ie. 15-20 drops). Fenistil drops may be administered undiluted or when added to milk.