• 100 mg thiamine hydrochloride
• 100 mg pyridoxine hydrochloride

• cellulose, microcrystalline
• cornstarch
• Carboxymethyl Starch, Sodium
• Silica, colloidal
• talc
• magnesium stearate
• hypromellose
• Macrogol 6000
• titanium dioxide

NEURO, nervous system disorders, pyridoxine hydrochloride, thiamine deficiency indication

• The preparation is a combination of neurotropic vitamins: thiamine (vitamin B ₁ ) and pyridoxine (vitamin B ₆ ).
• The drug is used for neurological systemic diseases caused by a proven deficiency of vitamins B ₁ and B ₆ .

NEURO, nervous system disorders, pyridoxine hydrochloride, thiamine deficiency dosage

• Always take this medicine exactly as described or as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
• The recommended dose is:
  • Adults
    • 1 film-coated tablet 1 to 3 times a day (equivalent to 100 - 300 mg vitamin B ₁ /vitamin B ₆ per day).
    • The maximum daily dose should not be exceeded.

• duration of use
  • After four weeks of therapy, the doctor should decide whether the administration of vitamins B1 _and B6 _in the high dosage is still necessary

• If you take more than you should
  • _{Vitamin B 1} taken orally is of low harmfulness (toxicity). Poisoning in the strict sense is unknown. Only very high doses (over 10 g) block or suppress (similar to curare) the transmission of stimuli from nerve cells.
  • The toxic potential of vitamin B ₆ is considered to be very low.
  • Long-term use (more than 6 - 12 months) of daily doses of more than 50 mg vitamin B ₆ and short-term use (longer than 2 months) of daily doses of more than 1 g vitamin B ₆ can cause abnormal sensations such as tingling or pins and needles in the hands and feet (peripheral sensory neuropathies).
  • The following symptoms have been observed in people who have taken more than 2 g of vitamin B _{6 per day:}
    • Nerve damage with movement disorders (neuropathies with ataxia)
    • sensory disturbances
    • Seizures (cerebral convulsions with EEG changes)
    • Anemia (hypochromic anemia)
    • Inflammation of the skin (seborrheic dermatitis).
  • In the event of an overdose, there are no substance-specific countermeasures; it must be treated according to the complaints.

• If you forget to take a dose
  • Do not take a double dose to make up for a forgotten dose.

• If you stop taking it
  • For successful treatment, it is important that you take the medicine for the entire length of time recommended by your doctor.

• If you have any further questions on the use of the medicine, ask your doctor or pharmacist.

NEURO, nervous system disorders, pyridoxine hydrochloride, thiamine deficiency way

• To take.
• The film-coated tablets are swallowed whole with or after meals with sufficient liquid (e.g. 1 glass of water).

side effects

• Like all medicines, this medicine can cause side effects, although not everyone gets them.
• possible side effects
  • Not known (cannot be estimated from the available data):
    • Hypersensitivity reactions (breaks into sweat, racing heart (tachycardia), skin reactions with itching and hives (urticaria)).
    • Long-term use (more than 6 - 12 months) of daily doses of more than 50 mg vitamin B ₆ and short-term use (longer than 2 months) of daily doses of more than 1 g vitamin B ₆ can cause abnormal sensations such as tingling or pins and needles in the hands and feet (peripheral sensory neuropathies).
• If you get any side effects, talk to your doctor or pharmacist. This also applies to side effects that are not specified.

NEURO, nervous system disorders, pyridoxine hydrochloride, thiamine deficiency interactions

• Taking with other medicines
  • Tell your doctor or pharmacist if you are taking/using, have recently taken/used or might take/use any other medicines.
  • Vitamin B ₆ reduces the effect of levodopa (medicine used to treat Parkinson's disease) if levodopa is used without decarboxylase inhibitors (carbidopa, benserazide).
  • When vitamin B ₆ is used at the same time as cycloserine (antibiotic), isoniazid (INH) (antibiotic), D-penicillamine (medicine to treat rheumatic diseases), hydralazine (medicine to treat high blood pressure) or hormonal contraceptives (the "pill") the need for vitamin B ₆ increases.

Contraindications

• The medicine must not be taken
  • if you are allergic to thiamine chloride hydrochloride (vitamin B ₁ ), pyridoxine hydrochloride (vitamin B ₆ ) or any of the other ingredients of the preparation.

pregnancy and breast feeding period

• If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
• During pregnancy and breastfeeding, the recommended daily intake for vitamin B ₁ is 1.4 - 1.6 mg and for vitamin B ₆ 2.4 - 2.6 mg. During pregnancy, these dosages may only be exceeded if the patient has a proven vitamin B ₁ and B ₆ deficiency, since the safety of using higher doses than the daily recommended dose has not yet been proven.
• Vitamin B ₁ and B ₆ pass into breast milk. High doses of vitamin B ₆ can inhibit milk production.
• The attending physician should decide to what extent this preparation may be used during pregnancy and breastfeeding.

patient NEURO, nervous system disorders, pyridoxine hydrochloride, thiamine deficiency notes

• Warnings and Precautions
  • Please talk to your doctor or pharmacist before taking this medicine.
    • if you experience abnormal sensations such as tingling or pins and needles in your hands and feet (peripheral sensory neuropathies).
      Peripheral sensory neuropathies have been observed with long-term use (more than 6-12 months) of daily doses of more than 50 mg vitamin B ₆ and with short-term use (longer than 2 months) of daily doses of more than 1 g vitamin B ₆ .

• Ability to drive and use machines
  • The medicine has no influence on the ability to drive and use machines.