VITAMIN B12 deficiency RATIOPHARM N ampoules 5X1 ml

ratiopharm GmbH

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VITAMIN B12 deficiency RATIOPHARM N ampoules 5X1 ml

✓ For vitamin B12 deficiency
✓ Vitamin preparation
✓ Ampoules (5 x 1 ml)

How does vitamin B12 deficiency manifest itself?


Most people get more than the recommended daily allowance of vitamin B12 from food. Nevertheless, around five percent of the population in Germany suffer from a vitamin B12 deficiency. Causes can be an unbalanced diet or an increased need, e.g. during pregnancy and breastfeeding.


Vitamin B12 deficiency can be caused by:


  • strictly vegetarian/vegan diet
  • absorption disorders from the intestine
  • certain medications that reduce gastric acid


⁠Symptoms of vitamin B12 deficiency include:


  • Anemia (megaloblastic anemia)
  • tiredness and lack of concentration
  • tingling and numbness

What does the body need vitamin B12 for?

Vitamin B12 plays an important role in various metabolic processes. In addition, vitamin B12 supports many important processes in the human organism. The most important tasks of vitamin B12 include:

  • Formation of red blood cells
  • Structure of the nervous system
  • Formation of new cells or cell division
  • Reduction of tiredness and fatigue
  • Formation of the neurotransmitter acetylcholine

What is the daily requirement of vitamin B12?

The daily requirement for vitamin B12 varies from person to person and can vary in certain life situations. The German Society for Nutrition (DGE) recommends the following daily dose:

  • Adolescents (15 years and older): about 3.0 micrograms
  • Adults: about 3.0 micrograms
  • Pregnant women: 3.5 to 4 micrograms

How can the vitamin B12 requirement be met?

Vitamin B12 cannot be produced by the body itself. It is the only water-soluble vitamin that is stored in large quantities in the liver. Vitamin B12 can be obtained from numerous foods. Good suppliers are meat, fish, eggs, milk and milk products . The vitamin can also be found in small amounts in plant products, for example in sauerkraut.

Vitamin B12 ratiopharm N ampoules

 Active substance: cyanocobalamin

Other ingredients: sodium chloride, sodium dihydrogen phosphate dihydrate, water for injections.

Areas of application:
Prevention of vitamin B12 deficiencies as a result of years of malnutrition and malnutrition.

Vitamin B12 deficiency can manifest itself in the following clinical pictures:

  • Hyperchromic macrocytic megaloblastic anemia (pernicious anemia, Biermer anemia, Addison's anemia; these are red blood cell maturation disorders)
  • funicular spinal disease (spinal cord damage)

A vitamin B12 deficiency confirmed by laboratory diagnostics can occur with:

  • years of malnutrition (e.g. strictly vegetarian diet)
  • Malabsorption (insufficient absorption of vitamin B12 in the intestine) due to:
  • Insufficient production of intrinsic factor (a protein that is formed in the gastric mucosa and is needed to absorb vitamin B12)
  • Diseases in the end section of the ileum (part of the small intestine), e.g. B. Sprue
  • fish tapeworm infestation or
  • Blind loop syndrome (change in the course of the intestine after gastric surgery)
  • congenital vitamin B12 transport disorders

Always use the preparation exactly as directed. Please check with your doctor or pharmacist if you are not sure.

Unless otherwise prescribed by the doctor, the usual dose is:

  • At the beginning of treatment, 1 ampoule (equivalent to 100 µg cyanocobalamin) is administered daily in the first few weeks after diagnosis.
  • If there is a proven vitamin B12 absorption disorder in the intestine, 1 ampoule (equivalent to 100 µg cyanocobalamin) is then administered once a month.

Duration of use
The preparation is intended for long-term use. Please ask your doctor about this.
Please talk to your doctor or pharmacist if you have the impression that the effect is too strong or too weak.
If you use more than you should

  • Poisoning or overdose symptoms are not known.

Side effects

Like all medicines, this preparation can cause side effects, although not everyone gets them.

Very rare (affects less than 1 user in 10,000):

  • Symptoms of hypersensitivity (anaphylactic or anaphylactoid reactions)
  • Skin symptoms (acne as well as eczematous and urticarial drug reactions)

If you get any side effects, talk to your doctor or pharmacist. This also applies to side effects that are not specified.


When used with other drugs

  • Please inform your doctor or pharmacist if you are taking/using or have recently taken/used other medicines, even if they are non-prescription medicines.
  • So far no interactions are known.
  • Due to the instability of vitamin B12, a loss of effectiveness of the vitamin can occur if other medicinal substances are added.

For medicines: Read the leaflet on the risks and side effects and ask your doctor or pharmacist.