• 1 mg hydroxocobalamin acetate

• water for injections
• Acetic acid for pH adjustment
• sodium chloride
• sodium acetate

1000 µg depot vitamin B12

Composition:
1 ampoule of 2 ml contains: hydroxocobalamin acetate 1000 µg (1mg) (depot vitamin B12)
Other ingredients: sodium acetate/acetic acid (acetate buffer), sodium chloride, water for injections.

Areas of application:
Vitamin B12 deficiency that cannot be remedied with nutrition. Vitamin B12 deficiency can manifest itself in the following clinical pictures:

• Hyperchromic macrocytic megaloblastic anemia (pernicious anemia, Biermer's anemia, Addison's anemia; these are disorders of maturation of the blood cells).
• Funicular spinal disease (spinal cord damage).

A vitamin B12 deficiency confirmed by laboratory diagnostics can occur:

• if you have been malnourished or malnourished for years (e.g. through a strict vegetarian diet),
• due to congenital vitamin B12 transport disorders
• in case of malabsorption (insufficient absorption of vitamin B12 in the intestine)
• due to insufficient production of the intrinsic factor (a protein that is formed in the gastric mucosa and is required for the absorption of vitamin B12),
• due to diseases in the end section of the ileum, e.g. sprue,
• by fish tapeworm,
• due to blind loop syndrome (change in the course of the intestine after gastric surgery).

Dosage:
Unless otherwise prescribed, 1 ml "Vitamin B12 Depot Hevert" (equivalent to 500 µg hydroxocobalamin acetate) is administered twice a week at the beginning of treatment in the first few weeks after diagnosis. If there is a proven vitamin B12 absorption disorder in the intestine, 100 µg hydroxocobalamin acetate are then administered once a month.

"Vitamin B12 Depot Hevert" is usually administered intramuscularly. However, it can also be given slowly intravenously. "Vitamin B12 Depot Hevert" is intended for long-term use. Poisoning and overdose symptoms are not known.

Contraindications:
intolerance of any component.

The recommended daily intake of vitamin B12 during pregnancy and breastfeeding is 4 µg. According to previous experience, higher application amounts have no adverse effects on the unborn child. Vitamin B12 is excreted in breast milk.

Side effects:
In individual cases, acne, eczematous and urticarial drug reactions and hypersensitivity symptoms (anaphylactic or anaphylactoid reactions).

Interactions:
None known.

As a catalyst, vitamin B12 has a decisive influence on carbohydrate, fat and protein metabolism and protein synthesis. In particular, nerve cell functions and the formation of red blood cells (erythropoiesis) depend on an adequate supply of vitamin B12.

The blood-forming tissues are the first to be affected by a vitamin B12 deficiency. But the nervous system is also affected by a B12 deficiency, because vitamin B12 is jointly responsible for the formation of the myelin sheaths in the nervous system. In clinical deficiency states, mostly as a result of insufficient resorption of vitamin B12, such as after extensive resection of the small intestine and irritation of the small intestine (dysbiosis of the intestine), the resorption area in the intestine is reduced or blocked. But even with a strict vegetarian diet and with tapeworm infestation, vitamin B12 deficiencies can occur.

Intrinsic factor deficiency can occur as a result of gastric mucosal diseases and after gastrectomy. This factor is essential for the absorption of vitamin B12 in the stomach. An intrinsic factor deficiency is often the cause of vitamin B12 deficiency.

The vitamin B12 contained in the body is stored in depots, of which the liver is the most important. After exhaustion of the liver reserves, there are disorders in the maturation of the red blood cells (pernicious anaemia), symptomatic psychoses and funicular spinal diseases, which initially manifest themselves as paresthesia with tingling sensations and weakened muscle tone, accompanied by depressive moods.

The parenteral application of "Vitamin B12 Depot Hevert" can quickly and permanently remedy the symptoms of illness caused by a lack of vitamin B12. Hydroxocobalamin is the physiological depot form of vitamin B12 and is particularly characterized by the following properties: Stronger binding to tissue proteins (liver accumulation), stronger binding to serum proteins, therefore delayed and lower excretion with the urine and thus a longer lasting effect. Hydroxocobalamin ensures a long-lasting effect.

Note:
"Vitamin B12 Depot Hevert" ampoules do not contain any preservatives.