HEPA MERZ infusion concentrate ampoules 25X10 ml liver failure

MERZ Pharmaceuticals GmbH

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Hepa-Merz solution for infusion concentrate liver failure


Active ingredient: L-ornithine-L-aspartate
Areas of application:
Hepa-Merz solution for infusion concentrate is used for the treatment of impaired consciousness due to liver failure (latent and manifest hepatic encephalopathy).

Active ingredient: ornithine aspartate

In the case of disturbed detoxification performance of the liver and the resulting disturbances of consciousness.

 

active HEPA MERZ infusion concentrate ampoules 25X10 ml liver failure ingredients

 

  • 5000 mg ornithine aspartate

HEPA MERZ infusion concentrate ampoules 25X10 ml liver failure excipients

  • water for injections

indication

  • The drug is a drug used to stimulate ammonia detoxification by increasing urea synthesis in the liver.
  • It is also used for ammonia detoxification in the tissue, i.e. outside the liver (extrahepatic).
  • The drug is used to treat impaired consciousness due to liver failure (latent and manifest hepatic encephalopathy).

HEPA MERZ infusion concentrate ampoules 25X10 ml liver failure dosage

  • Unless otherwise directed by your doctor, the usual dose is up to 4 ampoules daily. At the onset of impaired consciousness (pre-coma) and clouding of consciousness (coma), your doctor can administer up to 8 ampoules within 24 hours, depending on the severity of the condition.
  • Please talk to your doctor or pharmacist if you have the impression that the effect of the medicine is too strong or too weak.

 

  • If you use too much medicine:
    • To date, no symptoms of poisoning have been observed in the case of an overdose of ornithine partate. If necessary, your doctor will treat the symptoms you are experiencing

 

  • If you have any further questions on the use of the medicine, ask your doctor or pharmacist.

HEPA MERZ infusion concentrate ampoules 25X10 ml liver failure way

  • The medicinal product is a concentrate for making up a solution for infusion. Before use, your doctor will add the ampoules to an infusion solution and infuse the medicine in this form.
  • However, your doctor should only prepare the mixture immediately before use. However, for reasons of venous compatibility, your doctor should not dissolve more than 6 ampoules per 500 ml infusion.
  • The infusion rate is a maximum of 5 g ornithine partate (corresponding to the content of one ampoule) per hour.
  • The medicinal product must not be administered intra-arterially.

side effects

  • Like all medicines, the drug can have side effects, although not everyone gets them.
    • The frequency of side effects is based on the following categories:
      • Very common: affects more than 1 in 10 people
      • Common: affects 1 to 10 users in 100
      • Uncommon: affects 1 to 10 users in 1,000
      • Rare: affects 1 to 10 users in 10,000
      • Very rare: affects less than 1 in 10,000 people
      • Not known: frequency cannot be estimated from the available data
    • Possible side effects:
      • Uncommon: nausea
      • Rare: vomiting
      • Frequency not known: hypersensitivity, allergic (anaphylactic) reaction
      • Nausea and vomiting are generally transient and do not require discontinuation of the medicinal product, but resolve with dose or infusion rate reductions.
    • Please tell your doctor or pharmacist if any of the side effects gets serious, or if you notice any side effects not listed here.

HEPA MERZ infusion concentrate ampoules 25X10 ml liver failure interactions

  • When using the medicine with other medicines:
    • Please inform your doctor or pharmacist if you are taking/using or have recently taken/used other medicines, even if they are non-prescription medicines.
    • So far no interactions are known.

Contraindications

  • The drug must not be used
    • if you are allergic (hypersensitive) to ornithine partate or any of the other ingredients of the medicine
    • if you suffer from severe kidney dysfunction (renal insufficiency). A serum creatinine value of over 3 mg/100 ml can be used as a guideline.

pregnancy and breast feeding period

  • pregnancy and breast feeding period
    • The safety of using the drug during pregnancy and breastfeeding has not been proven.
    • If you want to become pregnant, are pregnant or breastfeeding, please inform your doctor.
    • Ask your doctor or pharmacist for advice before taking/using any medicine.

patient HEPA MERZ infusion concentrate ampoules 25X10 ml liver failure notes

  • Special care is required when using the drug
    • if high doses of the medicine are to be used. The urea level in the serum and urine should be checked by your doctor.
    • with severely impaired liver function. To avoid nausea and vomiting, your doctor will adjust the infusion rate individually for you.
    • There is no data available for use in children.

 

  • Driving and using machines:
    • Due to the disease, your ability to drive and use machines may also be affected during treatment with the medicine.