1 g of cream contains 100 mg etofenamatu and 10 mg of benzyl nicotinate.
non-steroidal anti-inflammatory drug from the group of anthranilic acid (fenamatów) with analgesic and anti-inflammatory topical. The mechanism of action by inhibiting the synthesis of prostaglandins, inhibition of release of mediators of inflammation (bradykinin, serotonin, histamine, proteolytic enzymes), blocking complement fixation and release of the inhibition of hyaluronidase. Benzyl nicotinate is locally irritating properties - causes local hyperemia and feeling of warmth. Dermal bioavailability is about 20% and depends on the local state (eg. Moisture). Peak plasma concentrations occur after 12-24 hours of application. In approximately 99% bound to plasma proteins. It is excreted in the form of a number of free or conjugated metabolites in the urine of 35%, the remainder of the bile and feces.
Osteoarthritis of the spine, knee, shoulder. Extra-articular rheumatism: pain in the lumbar-cross; lesions in articular soft tissues (bursitis, tendinitis, tendon sheaths, joint capsules); epicondylitis.
Hypersensitivity to etofenamate, flufenamic acid, benzyl nicotinate or other NSAIDs. Pregnancy and breast-feeding. Children under 14 years of age
Do not use on damaged skin or the affected.
Pregnancy and lactation:
Do not use in pregnant or breast-feeding.
The appropriate amount of the cream THERMO RHEUMON (usually 2 g, ie. The size of hazelnut) applied to the skin in the area covered by the pain and vigorously rubbed. Use 3-4 times a day. It can be used as a complement to thermotherapy. Treatment usually lasts for 2 weeks.