• gluten free
• gelatin free

Thiogamma ^® 600 orally.
Active ingredient: alpha lipoic acid 600 mg.
Areas of application: paresthesia in diabetic polyneuropathy.

For information on risks and side effects, read the package insert and ask your doctor or pharmacist.

Wörwag Pharma GmbH & Co. KG, 71034 Boeblingen

THIOGAMMA 600 oral film- coated tablets

Thiogamma ^® 600 oral: Effective in diabetic polyneuropathy
About every third patient with diabetes suffers from diabetic polyneuropathy. Typical symptoms such as tingling, numbness, burning or pain in the feet and hands can occur. The main cause of this nerve damage is oxidative stress, which is caused by the changed metabolism caused by diabetes. ^1,2,3

Thiogamma ^® 600 oral with the antioxidant alpha-lipoic acid offers an advantageous therapy option by helping the body to reduce oxidative stress. In this way, it counteracts the abnormal sensations that many people with diabetic nerve damage suffer from, and can thus improve the quality of life of those affected. ⁴

Thiogamma ^®600 orally with antioxidant alpha-lipoic acid:
• Relieves discomfort in diabetic polyneuropathy
• Well tolerated and suitable for long-term treatment
• Only 1 tablet daily
• Made in Germany
• Without a prescription in your pharmacy

Patients have been relying on the tried and tested German drug quality of for over 25 years Thiogamma ^® 600 orally. According to a study, when taking the recommended daily dose of 600 mg alpha lipoic acid, symptoms such as numbness, burning, tingling and pain can already be significantly reduced after 5 weeks. ⁵

Because it is well tolerated, oral alpha lipoic acid is suitable for long-term treatment.

Treating the cause and symptoms of diabetic polyneuropathy with alpha lipoic acid
Alpha lipoic acid combats a cause of diabetic polyneuropathy by scavenging free radicals and thus reducing increased oxidative stress. ⁶ This powerful antioxidant has proven itself in the relief of unpleasant symptoms in diabetic polyneuropathy such as tingling, burning and pain. ⁷

The special thing about alpha lipoic acid: It not only has an antioxidant effect itself, but also regenerates other important antioxidants for the body such as vitamins C and E. ⁶

RECOMMENDATION FOR USE:
To achieve optimum effectiveness, Thiogamma ^®600 should be taken orally as follows: 1 tablet daily, whole and with sufficient liquid, e.g. B. a glass of water. It should be taken on an empty stomach, about 30 minutes before the first meal. Do not take Thiogamma ^® 600 orally together with medication containing metal (e.g. magnesium or iron). When consuming dairy products, due to their calcium content, it is important to ensure that they are taken at different times.

DAILY SELF-CHECK
In addition to regular check-ups with a doctor, you should also thoroughly inspect your feet yourself every day. Are there any changes to the nails or skin? Do you recognize pressure points, cracks or fissures? A small hand mirror can be useful for a detailed examination or you can ask family members for help. You should report any abnormalities to your doctor.

REGULAR FOOTBATH - BUT RIGHT
A footbath should be done regularly - a maximum of 3 times a week - and not longer than approx. 3 minutes. Lukewarm water (30 to 37 ° C) is ideal. Be sure to check the water temperature with a thermometer! Do not use alcoholic bath additives or soaps. After the bath, dry the feet and the spaces between the toes thoroughly with a soft towel or blow-dry.

NAIL SCISSORS IS TABOO
Scissors, nail clippers or sharp nail files should not be used for foot care due to the risk of injury. This also applies to the use of corn plasters or caustic tinctures. A rounded sandpaper file is recommended for shortening the nails.

NEVER RUN BAREFOOT
When walking barefoot, you run the risk of running splinters, bumping your toes or injuring yourself in any other way. In summer there is also the risk of burning your feet from sun exposure or hot sand.

EYE UP WHEN SHOE SHOE ARE BUYING
To prevent pressure points or blisters from tight shoes, you should check the removed insole to see whether the shoe is wide enough. Also, feel out the inside of the shoes to make sure that there are no annoying seams or bumps. High heels are not recommended. It is best to buy new shoes in the early afternoon and break them in well. This can help to avoid improper stress.

Frequently asked questions and answers:

What is diabetic polyneuropathy?
It is the most common form of diabetic neuropathy. "Neuropathy" is the medical generic term for diseases of the nerves, "Poly" means that several nerves are affected at the same time.

Specifically, the increased blood sugar damages especially the particularly sensitive long nerve fibers that reach into the feet and toes. The problems usually arise on the tip of the toes of both feet and then spread to the lower legs and hands. The nerve damage can cause incorrect signals to be sent and the patient may feel abnormal sensations (e.g. tingling).

Why are the nerves damaged in diabetes?
Constantly high blood sugar levels cause nerve-damaging processes to be set in motion:
• Oxidative stress
• Inflammatory reactions
• Circulatory disorders

Oxidative stress, in particular, puts a heavy strain on the nerves. It occurs because more so-called free radicals - aggressive oxygen molecules that attack the body's own structures (e.g. nerve cells) - are formed in diabetes than can be intercepted by antioxidants. Antioxidants are substances that render these radicals harmless and thus protect the body from them. They are therefore also called “radical scavengers”.

What is Alpha Lipoic Acid?
Alpha lipoic acid is a natural fatty acid. The human body can produce some of them itself or take them in through food. ⁶ Broccoli, offal (kidneys, heart, liver), spinach and tomatoes contain a particularly large amount of alpha lipoic acid. ^6thAlpha-lipoic acid performs several important tasks in the body: It is a powerful antioxidant, protects cells from free radicals and thus reduces oxidative stress in the body. It is also involved in numerous metabolic reactions.

A particular advantage: Alpha lipoic acid is both water and fat soluble. ⁶ As a result, it can act in a wide variety of areas in the body ⁶ and counteract diabetes-related nerve damage and the abnormal sensations caused by it. The well-researched active ingredient has been used for more than 25 years against paresthesia in diabetic polyneuropathy.

¹ Vincent et al. Endocr Rev 2004 Aug; 25 (4): 612-628.
²Bönhof et al. Endocr Rev 2019 Feb 1; 40 (1): 153-192.
³ Brownlee. Diabetes 2005 Jun; 54 (6): 1615-1625.
⁴ Agathos et al. J Int Med Res 2018 May; 46 (5): 1779-1790.
⁵ Ziegler et al. Diabetes Care 2006 Nov; 29 (11): 2365-2370.
⁶ Rochette et al. Can J Physiol Phamacol 2015 Dec; 93 (12): 1021-1027.
⁷ Çakici et al. Diabet Med 2016 Nov; 33 (11): 1466-1476.